Integrating mutations data of the TP53 human gene in the bioinformatics network environment

Domenico Marra, Paolo Romano

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

We present in this paper some new network tools that can improve the accessibility of information on mutations of the TP53 human gene with the aims of allowing for the integration of this data in the growing bioinformatics network environment and of demonstrating a possible methodology for biological data integration. We implemented the IARC TP53 Mutations Database and related subsets in an SRS site, set up some Web Services allowing for a software oriented, programmatic access to this data, created some demo workflows that illustrate how to interact with Web Services and implemented these workflows in the biowep (Workflow Enactment Portal for Bioinformatics) system. In conclusion, we discuss a new flexible and adaptable methodology for data integration in the biomedical research application domain.

Original languageEnglish
Title of host publicationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Pages453-463
Number of pages11
Volume4414 LNBI
Publication statusPublished - 2007
Event1st International Conference on Bioinformatics Research and Development, BIRD 2007 - Berlin, Germany
Duration: Mar 12 2007Mar 14 2007

Other

Other1st International Conference on Bioinformatics Research and Development, BIRD 2007
CountryGermany
CityBerlin
Period3/12/073/14/07

Fingerprint

Workflow
Data integration
p53 Genes
Bioinformatics
Computational Biology
Web services
Work Flow
Mutation
Genes
Data Integration
Gene
Web Services
Portal System
Methodology
Accessibility
Biomedical Research
Software
Databases
Subset
Human

Keywords

  • Bioinformatics
  • Data integration
  • Molecular biology databases
  • Web services
  • Workflow enactment portal
  • Workflow management systems
  • XML

ASJC Scopus subject areas

  • Computer Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Theoretical Computer Science

Cite this

Marra, D., & Romano, P. (2007). Integrating mutations data of the TP53 human gene in the bioinformatics network environment. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 4414 LNBI, pp. 453-463)

Integrating mutations data of the TP53 human gene in the bioinformatics network environment. / Marra, Domenico; Romano, Paolo.

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 4414 LNBI 2007. p. 453-463.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Marra, D & Romano, P 2007, Integrating mutations data of the TP53 human gene in the bioinformatics network environment. in Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). vol. 4414 LNBI, pp. 453-463, 1st International Conference on Bioinformatics Research and Development, BIRD 2007, Berlin, Germany, 3/12/07.
Marra D, Romano P. Integrating mutations data of the TP53 human gene in the bioinformatics network environment. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 4414 LNBI. 2007. p. 453-463
Marra, Domenico ; Romano, Paolo. / Integrating mutations data of the TP53 human gene in the bioinformatics network environment. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 4414 LNBI 2007. pp. 453-463
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