Integrating Myc and TGF-β signalling in cell-cycle control

Research output: Contribution to journalArticlepeer-review


Expression of the cell cycle inhibitor p15INK4b is suppressed by the Myc oncoprotein and induced by transforming growth factor-β (TGF-β). The transcription factor Miz-1 activates the Ink4b promoter, and interacts with Myc and TGF-β-activated Smad proteins. Miz-1 is thus a point of convergence for these antagonistic signals in cell-cycle control.

Original languageEnglish
JournalNature Cell Biology
Issue number5
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Cell Biology


Dive into the research topics of 'Integrating Myc and TGF-β signalling in cell-cycle control'. Together they form a unique fingerprint.

Cite this