Integrating Myc and TGF-β signalling in cell-cycle control

Research output: Contribution to journalArticlepeer-review

Abstract

Expression of the cell cycle inhibitor p15INK4b is suppressed by the Myc oncoprotein and induced by transforming growth factor-β (TGF-β). The transcription factor Miz-1 activates the Ink4b promoter, and interacts with Myc and TGF-β-activated Smad proteins. Miz-1 is thus a point of convergence for these antagonistic signals in cell-cycle control.

Original languageEnglish
JournalNature Cell Biology
Volume3
Issue number5
DOIs
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Cell Biology

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