Integrating Myc and TGF-β signalling in cell-cycle control

B. Amati

doi:10.1038/35074634

Integrating Myc and TGF-β signalling in cell-cycle control

B. Amati

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

Expression of the cell cycle inhibitor p15^INK4b is suppressed by the Myc oncoprotein and induced by transforming growth factor-β (TGF-β). The transcription factor Miz-1 activates the Ink4b promoter, and interacts with Myc and TGF-β-activated Smad proteins. Miz-1 is thus a point of convergence for these antagonistic signals in cell-cycle control.

Original language	English
Journal	Nature Cell Biology
Volume	3
Issue number	5
DOIs	https://doi.org/10.1038/35074634
Publication status	Published - 2001

ASJC Scopus subject areas

Cell Biology

Access to Document

10.1038/35074634

Fingerprint Dive into the research topics of 'Integrating Myc and TGF-β signalling in cell-cycle control'. Together they form a unique fingerprint.

Cite this

@article{e4dd368c3bef46c69dc861bda13bbb09,

title = "Integrating Myc and TGF-β signalling in cell-cycle control",

abstract = "Expression of the cell cycle inhibitor p15INK4b is suppressed by the Myc oncoprotein and induced by transforming growth factor-β (TGF-β). The transcription factor Miz-1 activates the Ink4b promoter, and interacts with Myc and TGF-β-activated Smad proteins. Miz-1 is thus a point of convergence for these antagonistic signals in cell-cycle control.",

author = "B. Amati",

year = "2001",

doi = "10.1038/35074634",

language = "English",

volume = "3",

journal = "Nature Cell Biology",

issn = "1465-7392",

publisher = "Nature Publishing Group",

number = "5",

}

TY - JOUR

T1 - Integrating Myc and TGF-β signalling in cell-cycle control

AU - Amati, B.

PY - 2001

Y1 - 2001

N2 - Expression of the cell cycle inhibitor p15INK4b is suppressed by the Myc oncoprotein and induced by transforming growth factor-β (TGF-β). The transcription factor Miz-1 activates the Ink4b promoter, and interacts with Myc and TGF-β-activated Smad proteins. Miz-1 is thus a point of convergence for these antagonistic signals in cell-cycle control.

AB - Expression of the cell cycle inhibitor p15INK4b is suppressed by the Myc oncoprotein and induced by transforming growth factor-β (TGF-β). The transcription factor Miz-1 activates the Ink4b promoter, and interacts with Myc and TGF-β-activated Smad proteins. Miz-1 is thus a point of convergence for these antagonistic signals in cell-cycle control.

UR - http://www.scopus.com/inward/record.url?scp=0035011486&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035011486&partnerID=8YFLogxK

U2 - 10.1038/35074634

DO - 10.1038/35074634

M3 - Article

C2 - 11331894

AN - SCOPUS:0035011486

VL - 3

JO - Nature Cell Biology

JF - Nature Cell Biology

SN - 1465-7392

IS - 5

ER -