Integrating Myc and TGF-β signalling in cell-cycle control

B. Amati

doi:10.1038/35074634

Integrating Myc and TGF-β signalling in cell-cycle control

B. Amati

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

Expression of the cell cycle inhibitor p15^INK4b is suppressed by the Myc oncoprotein and induced by transforming growth factor-β (TGF-β). The transcription factor Miz-1 activates the Ink4b promoter, and interacts with Myc and TGF-β-activated Smad proteins. Miz-1 is thus a point of convergence for these antagonistic signals in cell-cycle control.

Original language	English
Journal	Nature Cell Biology
Volume	3
Issue number	5
DOIs	https://doi.org/10.1038/35074634
Publication status	Published - 2001

ASJC Scopus subject areas

Cell Biology

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title = "Integrating Myc and TGF-β signalling in cell-cycle control",

abstract = "Expression of the cell cycle inhibitor p15INK4b is suppressed by the Myc oncoprotein and induced by transforming growth factor-β (TGF-β). The transcription factor Miz-1 activates the Ink4b promoter, and interacts with Myc and TGF-β-activated Smad proteins. Miz-1 is thus a point of convergence for these antagonistic signals in cell-cycle control.",

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Integrating Myc and TGF-β signalling in cell-cycle control

Abstract

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