Abstract
Expression of the cell cycle inhibitor p15INK4b is suppressed by the Myc oncoprotein and induced by transforming growth factor-β (TGF-β). The transcription factor Miz-1 activates the Ink4b promoter, and interacts with Myc and TGF-β-activated Smad proteins. Miz-1 is thus a point of convergence for these antagonistic signals in cell-cycle control.
Original language | English |
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Journal | Nature Cell Biology |
Volume | 3 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2001 |
ASJC Scopus subject areas
- Cell Biology