Integration between in vivo dosimetry and image guided radiotherapy for lung tumors

Angelo Piermattei, Savino Cilla, Luca Grimaldi, Domenico Sabatino, Andrea Fidanzio, Francesca Greco, Alessandra Mameli, Mario Balducci, Gian Carlo Mattiucci, Vincenzo Frascino, Gerardina Stimato, Diego Gaudino, Sara Ramella, Lucio Trodella, Guido D'Onofrio, Giampaolo Zini, Gabriella MacChia, Cinzia Digesu', Alessio G. Morganti, Stefania Clemente & 3 others Mariella Cozzolino, Piernicola Pedicini, Vincenzo Fusco

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The article reports a feasibility study about the potentiality of an in vivo dosimetry method for the adaptive radiotherapy of the lung tumors treated by 3D conformal radiotherapy techniques (3D CRTs). At the moment image guided radiotherapy (IGRT) has been used for this aim, but it requires taking many periodic radiological images during the treatment that increase workload and patient dose. In vivo dosimetry reported here can reduce the above efforts, alerting the medical staff for the commissioning of new radiological images for an eventual adaptive plan. The in vivo dosimetry method applied on 20 patients makes use of the transit signal St on the beam central axis measured by a small ion chamber positioned on an electronic portal imaging device (EPID) or by the EPID itself. The reconstructed in vivo dosimetry at the isocenter point Diso requires a convolution between the transit signal St and a dose reconstruction factor C that essentially depends on (i) tissue inhomogeneities along the beam central axis and (ii) the in-patient isocenter depth. The C factors, one for every gantry angle, are obtained by processing the patient's computed tomography scan. The method has been recently applied in some Italian centers to check the radiotherapy of pelvis, breast, head, and thorax treatments. In this work the dose reconstruction was carried out in five centers to check the Diso in the lung tumor during the 3D CRT, and the results have been used to detect the interfraction tumor anatomy variations that can require new CT imaging and an adaptive plan. In particular, in three centers a small ion chamber was positioned below the patient and used for the St measurement. In two centers, the St signal was obtained directly by 25 central pixels of an a-Si EPID, equipped with commercial software that enabled its use as a stable detector. A tolerance action level of ±6% for every checked beam was assumed. This means that when a difference greater than 6% between the predicted dose by the treatment planning system, Diso,TPS, and the Diso was observed, the clinical action started to detect possible errors. 60% of the patients examined presented morphological changes during the treatment that were checked by the in vivo dosimetry and successively confirmed by the new CT scans. In this work, a patient that showed for all beams Diso values outside the tolerance level, new CT scans were commissioned for an adaptive plan. Thelung dose volume histograms (DVHs) for a Diso,TPS =2 Gy for fraction suggested the adaptive plan to reduce the dose in lung tissue. The results of this research show that the dose guided radiotherapy (DGRT) by the Diso reconstruction was feasible for daily or periodic investigation on morphological lung tumor changes. In other words, since during 3D CRT treatments the anatomical lung tumor changes occur frequently, the DGRT can be well integrated with the IGRT.

Original languageEnglish
Pages (from-to)2206-2214
Number of pages9
JournalMedical Physics
Volume36
Issue number6
DOIs
Publication statusPublished - 2009

Fingerprint

Image-Guided Radiotherapy
Lung
Radiotherapy
Neoplasms
Equipment and Supplies
Ions
Conformal Radiotherapy
Therapeutics
Medical Staff
Feasibility Studies
In Vivo Dosimetry
Workload
Pelvis
Anatomy
Breast
Thorax
Software
Head
Tomography

Keywords

  • Guided radiotherapy
  • In vivo dosimetry
  • Portal dosimetry
  • Quality assurance in radiotherapy

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging

Cite this

Piermattei, A., Cilla, S., Grimaldi, L., Sabatino, D., Fidanzio, A., Greco, F., ... Fusco, V. (2009). Integration between in vivo dosimetry and image guided radiotherapy for lung tumors. Medical Physics, 36(6), 2206-2214. https://doi.org/10.1118/1.3129158

Integration between in vivo dosimetry and image guided radiotherapy for lung tumors. / Piermattei, Angelo; Cilla, Savino; Grimaldi, Luca; Sabatino, Domenico; Fidanzio, Andrea; Greco, Francesca; Mameli, Alessandra; Balducci, Mario; Mattiucci, Gian Carlo; Frascino, Vincenzo; Stimato, Gerardina; Gaudino, Diego; Ramella, Sara; Trodella, Lucio; D'Onofrio, Guido; Zini, Giampaolo; MacChia, Gabriella; Digesu', Cinzia; Morganti, Alessio G.; Clemente, Stefania; Cozzolino, Mariella; Pedicini, Piernicola; Fusco, Vincenzo.

In: Medical Physics, Vol. 36, No. 6, 2009, p. 2206-2214.

Research output: Contribution to journalArticle

Piermattei, A, Cilla, S, Grimaldi, L, Sabatino, D, Fidanzio, A, Greco, F, Mameli, A, Balducci, M, Mattiucci, GC, Frascino, V, Stimato, G, Gaudino, D, Ramella, S, Trodella, L, D'Onofrio, G, Zini, G, MacChia, G, Digesu', C, Morganti, AG, Clemente, S, Cozzolino, M, Pedicini, P & Fusco, V 2009, 'Integration between in vivo dosimetry and image guided radiotherapy for lung tumors', Medical Physics, vol. 36, no. 6, pp. 2206-2214. https://doi.org/10.1118/1.3129158
Piermattei A, Cilla S, Grimaldi L, Sabatino D, Fidanzio A, Greco F et al. Integration between in vivo dosimetry and image guided radiotherapy for lung tumors. Medical Physics. 2009;36(6):2206-2214. https://doi.org/10.1118/1.3129158
Piermattei, Angelo ; Cilla, Savino ; Grimaldi, Luca ; Sabatino, Domenico ; Fidanzio, Andrea ; Greco, Francesca ; Mameli, Alessandra ; Balducci, Mario ; Mattiucci, Gian Carlo ; Frascino, Vincenzo ; Stimato, Gerardina ; Gaudino, Diego ; Ramella, Sara ; Trodella, Lucio ; D'Onofrio, Guido ; Zini, Giampaolo ; MacChia, Gabriella ; Digesu', Cinzia ; Morganti, Alessio G. ; Clemente, Stefania ; Cozzolino, Mariella ; Pedicini, Piernicola ; Fusco, Vincenzo. / Integration between in vivo dosimetry and image guided radiotherapy for lung tumors. In: Medical Physics. 2009 ; Vol. 36, No. 6. pp. 2206-2214.
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AU - Greco, Francesca

AU - Mameli, Alessandra

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