Abstract
Introduction: Radioembolisation (selective internal radiation therapy; SIRT), as part of a continuous strategy contributed to the improvement in response rates and median survival for unresectable metastatic colorectal cancer. Therefore, the role of SIRT in the different stages of treatment plan was investigated in this review. Areas covered: After a brief description of the principles of SIRT, the review focused on the clinical evidences of published trials on the current experience of radioembolisation and its role in both salvage setting and earlier lines of chemotherapy. Expert opinion: Evidence from Phase I studies and small Phase II/III randomised controlled trials has provided an early signal of the safety and improved overall survival, which can be achieved with radioembolisation and chemotherapy compared with chemotherapy (alone), due to an improved liver control. In the salvage setting, interesting results were observed in term of response, toxicity and median overall survival. Until the results of these early-line randomised trials will be available, radioembolisation could be considered either alone or combined with an appropriate chemotherapy regimen following failure of first- or second-line therapy.
| Original language | English |
|---|---|
| Journal | Expert Opinion on Therapeutic Targets |
| Volume | 16 |
| Issue number | SUPPL.2 |
| DOIs | |
| Publication status | Published - Apr 2012 |
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Keywords
- Y
- colorectal cancer
- liver
- metastases
- radioembolisation
- selective internal radiotherapy
- SIRT
- yttrium-90 resin microspheres
ASJC Scopus subject areas
- Drug Discovery
- Pharmacology
- Clinical Biochemistry
- Molecular Medicine
Cite this
Integration of radioembolisation into multimodal treatment of liver-dominant metastatic colorectal cancer. / Cosimelli, Maurizio; Mancini, Raffaello; Carpanese, Livio; Sciuto, Rosa; Pizzi, Giuseppe; Pattaro, Giada; Maini, Carlo Ludovico.
In: Expert Opinion on Therapeutic Targets, Vol. 16, No. SUPPL.2, 04.2012.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Integration of radioembolisation into multimodal treatment of liver-dominant metastatic colorectal cancer
AU - Cosimelli, Maurizio
AU - Mancini, Raffaello
AU - Carpanese, Livio
AU - Sciuto, Rosa
AU - Pizzi, Giuseppe
AU - Pattaro, Giada
AU - Maini, Carlo Ludovico
PY - 2012/4
Y1 - 2012/4
N2 - Introduction: Radioembolisation (selective internal radiation therapy; SIRT), as part of a continuous strategy contributed to the improvement in response rates and median survival for unresectable metastatic colorectal cancer. Therefore, the role of SIRT in the different stages of treatment plan was investigated in this review. Areas covered: After a brief description of the principles of SIRT, the review focused on the clinical evidences of published trials on the current experience of radioembolisation and its role in both salvage setting and earlier lines of chemotherapy. Expert opinion: Evidence from Phase I studies and small Phase II/III randomised controlled trials has provided an early signal of the safety and improved overall survival, which can be achieved with radioembolisation and chemotherapy compared with chemotherapy (alone), due to an improved liver control. In the salvage setting, interesting results were observed in term of response, toxicity and median overall survival. Until the results of these early-line randomised trials will be available, radioembolisation could be considered either alone or combined with an appropriate chemotherapy regimen following failure of first- or second-line therapy.
AB - Introduction: Radioembolisation (selective internal radiation therapy; SIRT), as part of a continuous strategy contributed to the improvement in response rates and median survival for unresectable metastatic colorectal cancer. Therefore, the role of SIRT in the different stages of treatment plan was investigated in this review. Areas covered: After a brief description of the principles of SIRT, the review focused on the clinical evidences of published trials on the current experience of radioembolisation and its role in both salvage setting and earlier lines of chemotherapy. Expert opinion: Evidence from Phase I studies and small Phase II/III randomised controlled trials has provided an early signal of the safety and improved overall survival, which can be achieved with radioembolisation and chemotherapy compared with chemotherapy (alone), due to an improved liver control. In the salvage setting, interesting results were observed in term of response, toxicity and median overall survival. Until the results of these early-line randomised trials will be available, radioembolisation could be considered either alone or combined with an appropriate chemotherapy regimen following failure of first- or second-line therapy.
KW - Y
KW - colorectal cancer
KW - liver
KW - metastases
KW - radioembolisation
KW - selective internal radiotherapy
KW - SIRT
KW - yttrium-90 resin microspheres
UR - http://www.scopus.com/inward/record.url?scp=84858964969&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84858964969&partnerID=8YFLogxK
U2 - 10.1517/14728222.2011.647811
DO - 10.1517/14728222.2011.647811
M3 - Article
C2 - 22443155
AN - SCOPUS:84858964969
VL - 16
JO - Expert Opinion on Therapeutic Targets
JF - Expert Opinion on Therapeutic Targets
SN - 1472-8222
IS - SUPPL.2
ER -