Integrative systems medicine approaches to identify molecular targets in lymphoid malignancies

Raffaele Frazzi, Charles Auffray, Angela Ferrari, Perla Filippini, Sergio Rutella, Alfredo Cesario

Research output: Contribution to journalReview articlepeer-review


Although survival rates for lymphoproliferative disorders are steadily increasing both in the US and in Europe, there is need for optimizing front-line therapies and developing more effective salvage strategies. Recent advances in molecular genetics have highlighted the biological diversity of lymphoproliferative disorders. In particular, integrative approaches including whole genome sequencing, whole exome sequencing, and transcriptome or RNA sequencing have been instrumental to the identification of molecular targets for treatment. Herein, we will discuss how genomic, epigenomic and proteomic approaches in lymphoproliferative disorders have supported the discovery of molecular lesions and their therapeutic targeting in the clinic.

Original languageEnglish
Article number252
JournalJournal of Translational Medicine
Issue number1
Publication statusPublished - Sep 1 2016


  • High throughput RNA sequencing
  • Lymphoproliferative disorder
  • Massively-Parallel sequencing
  • Systems medicine

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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