Integrin-β4 is a novel transcriptional target of TAp73

Ningxia Xie, Polina Vikhreva, Margherita Annicchiarico-Petruzzelli, Ivano Amelio, Nicolai Barlev, Richard A. Knight, Gerry Melino

Research output: Contribution to journalArticle

Abstract

As a member of p53 family, p73 has attracted intense investigations due to its structural and functional similarities to p53. Among more than ten p73 variants, the transactivation (TA) domain-containing isoform TAp73 is the one that imitates the p53's behavior most. TAp73 induces apoptosis and cell cycle arrest, which endows it the capacity of tumour suppression. Also, it can exert diverse biological influences on cells through activating a complex and context dependent transcriptional programme. The transcriptional activities further broaden its roles in more intricate biological processes. In this article, we report that p73 is a positive regulator of a cell adhesion related gene named integrin β4 (ITGB4). This finding may have implications for the dissection of the biological mechanisms underlining p73 functions.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalCell Cycle
DOIs
Publication statusE-pub ahead of print - Feb 8 2018

Keywords

  • adhesion and migration
  • cancer cells
  • cell interaction
  • Integrins
  • oncogenes and tumor suppressors
  • oncosupression
  • p53 family
  • p73
  • transcription factors

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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