Integrin expression in middle ear cholesteatoma

Stefano Dallari, Andrea Cavani, Giuseppe Bergamini, Giampiero Girolomoni

Research output: Contribution to journalArticlepeer-review


Cholesteatoma is lined by a squamous keratinizing epithelium exhibiting most of the features of normal epidermis. In this study, we investigated by immunohistochemistry the expression of integrin adhesion molecules in primary acquired and recurrent cholesteatomas, and compared it with common epidermal cysts and normal human skin. The results showed that cholesteatoma epithelium exhibited a markedly augmented expression of αv integrin subunit and a corresponding increased deposition of vitronectin (αv ligand) in the surrounding stroma as compared to epidermal cyst and normal human skin. In contrast, the expression pattern of α2β1, α 3β1, and α6β4 integrins as well as the distribution of laminin, collagen IV and fibronectin were similar in cholesteatomas, epidermal cysts and normal human skin. Similar staining pattern was observed in primary acquired and recurrent cholesteatoma.

Original languageEnglish
Pages (from-to)188-192
Number of pages5
JournalActa Oto-Laryngologica
Issue number2
Publication statusPublished - 1994


  • Adhesion molecules
  • Immunohistochemistry
  • Middle ear
  • Vitronectin

ASJC Scopus subject areas

  • Otorhinolaryngology


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