Integrin expression in middle ear cholesteatoma

Stefano Dallari, Andrea Cavani, Giuseppe Bergamini, Giampiero Girolomoni

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Cholesteatoma is lined by a squamous keratinizing epithelium exhibiting most of the features of normal epidermis. In this study, we investigated by immunohistochemistry the expression of integrin adhesion molecules in primary acquired and recurrent cholesteatomas, and compared it with common epidermal cysts and normal human skin. The results showed that cholesteatoma epithelium exhibited a markedly augmented expression of αv integrin subunit and a corresponding increased deposition of vitronectin (αv ligand) in the surrounding stroma as compared to epidermal cyst and normal human skin. In contrast, the expression pattern of α2β1, α 3β1, and α6β4 integrins as well as the distribution of laminin, collagen IV and fibronectin were similar in cholesteatomas, epidermal cysts and normal human skin. Similar staining pattern was observed in primary acquired and recurrent cholesteatoma.

Original languageEnglish
Pages (from-to)188-192
Number of pages5
JournalActa Oto-Laryngologica
Volume114
Issue number2
DOIs
Publication statusPublished - 1994

Fingerprint

Middle Ear Cholesteatoma
Cholesteatoma
Integrins
Epidermal Cyst
Skin
Epithelium
Vitronectin
Laminin
Fibronectins
Epidermis
Collagen
Immunohistochemistry
Staining and Labeling
Ligands

Keywords

  • Adhesion molecules
  • Immunohistochemistry
  • Middle ear
  • Vitronectin

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Dallari, S., Cavani, A., Bergamini, G., & Girolomoni, G. (1994). Integrin expression in middle ear cholesteatoma. Acta Oto-Laryngologica, 114(2), 188-192. https://doi.org/10.3109/00016489409126040

Integrin expression in middle ear cholesteatoma. / Dallari, Stefano; Cavani, Andrea; Bergamini, Giuseppe; Girolomoni, Giampiero.

In: Acta Oto-Laryngologica, Vol. 114, No. 2, 1994, p. 188-192.

Research output: Contribution to journalArticle

Dallari, S, Cavani, A, Bergamini, G & Girolomoni, G 1994, 'Integrin expression in middle ear cholesteatoma', Acta Oto-Laryngologica, vol. 114, no. 2, pp. 188-192. https://doi.org/10.3109/00016489409126040
Dallari, Stefano ; Cavani, Andrea ; Bergamini, Giuseppe ; Girolomoni, Giampiero. / Integrin expression in middle ear cholesteatoma. In: Acta Oto-Laryngologica. 1994 ; Vol. 114, No. 2. pp. 188-192.
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