Integrin signaling and lung cancer

Francesca Caccavari, Donatella Valdembri, Chiara Sandri, Federico Bussolino, Guido Serini

Research output: Contribution to journalArticlepeer-review

Abstract

The poor prognosis of most non small cell lung carcinomas is due to their ability to effi ciently invade surrounding tissues and blood vessels, finally metastasizing to distant organs. integrin mediated adhesive interaction with the surrounding extracellular matrix is a key limiting step in the regulation of the invasive properties of several cancer cell types. Here, we examine the rising evidences about the role that integrins can play in the physiopathology of non small cell lung carcinomas by regulating cell adhesion as well as the activation of growth factors and the traffi c of their cognate receptors. Modulation of the signaling pathways controlled by integrins in lung cancer cells might offer the opportunity to design and develop new drugs that might be successfully combined with conventional chemotherapy and radiotherapy.

Original languageEnglish
Pages (from-to)124-129
Number of pages6
JournalCell Adhesion and Migration
Volume4
Issue number1
DOIs
Publication statusPublished - Jan 2010

Keywords

  • Fibronectin
  • Integrins
  • Lung cancer
  • Metastasis
  • Traffic

ASJC Scopus subject areas

  • Cell Biology
  • Cellular and Molecular Neuroscience

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