Integrins and adhesion molecules as targets to treat inflammatory bowel disease

Ivana Bravatà, Mariangela Allocca, Gionata Fiorino, Silvio Danese

Research output: Contribution to journalArticlepeer-review


Inflammatory bowel diseases (IBD) present a typically relapsing-remitting behavior and are characterized by a disabling and progressive course. Anti-tumor necrosis factor (TNF)-α agents have drastically changed the therapeutic management of IBD. However, a significant proportion of patients does not have a primary response, some patients lose response overtime and/or experience side effects. Recently, anti-adhesion molecules were investigated and showed efficacy with a good safety profile. Vedolizumab was recently approved for both Crohn's disease (CD) and ulcerative colitis (UC) and several other molecules are under evaluation in this field. Anti-adhesion molecules could represent a potential therapeutic option for future therapy in IBD. In this review we report the efficacy and safety of major anti-adhesion drugs in active IBD patients.

Original languageEnglish
Pages (from-to)67-71
Number of pages5
JournalCurrent Opinion in Pharmacology
Publication statusPublished - Dec 1 2015

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology


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