Integrins and angiogenesis

A sticky business

Research output: Contribution to journalArticle

156 Citations (Scopus)

Abstract

From an evolutionary point of view, the development of a cardiovascular system allowed vertebrates to nourish the several organs that compose their wider multicellular organism and to survive. Acquisition of new genes encoding for extracellular matrix (ECM) proteins and their cognate integrin receptors as well as secreted pro- and anti-angiogenic factors proved to be essential for the development of vascular networks in the vertebrate embryo. Postnatal tissue neo-vascularization plays a key role during wound healing and pathological angiogenesis as well. There is now clear evidence that building blood vessels in the embryo and in the adult organism relies upon different endothelial integrins and ECM ligands. A successful vascular development depends on fibronectin and its major receptor α5β1 integrin, but not on αvβ3, αvβ5, and α6β4 integrins that are instead central regulators of postnatal tumor angiogenesis. Here, endothelial αvβ3 elicits anti- or pro-angiogenic signals depending respectively on whether it is occupied by a soluble (e.g. type IV collagen derived tumstatin) or an insoluble (vitronectin) ECM ligand. The laminin-5 receptor α6β4 integrin, expressed only by endothelial cells of mature blood vessels, controls the invasive phase of tumor angiogenesis in the adult organism. Finally, regulation of vascular morphogenesis relies upon the fine modulation of integrin activation by chemoattractant and chemorepulsive cues, such as angiogenic growth factors and semaphorins.

Original languageEnglish
Pages (from-to)651-658
Number of pages8
JournalExperimental Cell Research
Volume312
Issue number5
DOIs
Publication statusPublished - Mar 10 2006

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Integrins
Blood Vessels
Angiogenesis Inducing Agents
Extracellular Matrix
Vertebrates
Embryonic Structures
Laminin Receptors
Semaphorins
Pathologic Neovascularization
Ligands
Vitronectin
Collagen Type IV
Extracellular Matrix Proteins
Chemotactic Factors
Cardiovascular System
Morphogenesis
Fibronectins
Wound Healing
Cues
Neoplasms

Keywords

  • Angiogenesis
  • Growth factors
  • Integrins
  • Semaphorins

ASJC Scopus subject areas

  • Cell Biology

Cite this

Integrins and angiogenesis : A sticky business. / Serini, Guido; Valdembri, Donatella; Bussolino, Federico.

In: Experimental Cell Research, Vol. 312, No. 5, 10.03.2006, p. 651-658.

Research output: Contribution to journalArticle

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