Abstract
Integrin signaling has a critical function in organizing cells in tissues during both embryonic development and tissue repair. Following their binding to the extracellular ligands, the intracellular signaling pathways triggered by integrins are directed to two major functions: organization of the actin cytoskeleton and regulation of cell behaviour including survival, differentiation and growth. Basic research conducted in the past twelve years has lead to remarkable breakthroughs in this field. Integrins are catalytically inactive and translate positional cues into biochemical signals by direct and/or functional association with intracellular adaptors, cytosolic tyrosine kinases or growth factor and cytokine receptors. The purpose of this chapter is to highlight recent experimental and conceptual advances in integrin signaling with particular emphasis on the ability of integrins to regulate Fak/Src family kinases (SFKs) activation and the cross-talk with soluble growth factors receptors and cytokines.
| Original language | English |
|---|---|
| Title of host publication | Advances in Experimental Medicine and Biology |
| Pages | 43-54 |
| Number of pages | 12 |
| Volume | 674 |
| DOIs | |
| Publication status | Published - 2010 |
Publication series
| Name | Advances in Experimental Medicine and Biology |
|---|---|
| Volume | 674 |
| ISSN (Print) | 00652598 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Integrins and signal transduction. / Cabodi, Sara; Di Stefano, Paola; Leal, Maria Del Pilar Camacho; Tinnirello, Agata; Bisaro, Brigitte; Morello, Virginia; Damiano, Laura; Aramu, Simona; Repetto, Daniele; Tornillo, Giusy; Defilippi, Paola.
Advances in Experimental Medicine and Biology. Vol. 674 2010. p. 43-54 (Advances in Experimental Medicine and Biology; Vol. 674).Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Integrins and signal transduction
AU - Cabodi, Sara
AU - Di Stefano, Paola
AU - Leal, Maria Del Pilar Camacho
AU - Tinnirello, Agata
AU - Bisaro, Brigitte
AU - Morello, Virginia
AU - Damiano, Laura
AU - Aramu, Simona
AU - Repetto, Daniele
AU - Tornillo, Giusy
AU - Defilippi, Paola
PY - 2010
Y1 - 2010
N2 - Integrin signaling has a critical function in organizing cells in tissues during both embryonic development and tissue repair. Following their binding to the extracellular ligands, the intracellular signaling pathways triggered by integrins are directed to two major functions: organization of the actin cytoskeleton and regulation of cell behaviour including survival, differentiation and growth. Basic research conducted in the past twelve years has lead to remarkable breakthroughs in this field. Integrins are catalytically inactive and translate positional cues into biochemical signals by direct and/or functional association with intracellular adaptors, cytosolic tyrosine kinases or growth factor and cytokine receptors. The purpose of this chapter is to highlight recent experimental and conceptual advances in integrin signaling with particular emphasis on the ability of integrins to regulate Fak/Src family kinases (SFKs) activation and the cross-talk with soluble growth factors receptors and cytokines.
AB - Integrin signaling has a critical function in organizing cells in tissues during both embryonic development and tissue repair. Following their binding to the extracellular ligands, the intracellular signaling pathways triggered by integrins are directed to two major functions: organization of the actin cytoskeleton and regulation of cell behaviour including survival, differentiation and growth. Basic research conducted in the past twelve years has lead to remarkable breakthroughs in this field. Integrins are catalytically inactive and translate positional cues into biochemical signals by direct and/or functional association with intracellular adaptors, cytosolic tyrosine kinases or growth factor and cytokine receptors. The purpose of this chapter is to highlight recent experimental and conceptual advances in integrin signaling with particular emphasis on the ability of integrins to regulate Fak/Src family kinases (SFKs) activation and the cross-talk with soluble growth factors receptors and cytokines.
UR - http://www.scopus.com/inward/record.url?scp=77954685078&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77954685078&partnerID=8YFLogxK
U2 - 10.1007/978-1-4419-6066-5_5
DO - 10.1007/978-1-4419-6066-5_5
M3 - Chapter
C2 - 20549939
AN - SCOPUS:77954685078
SN - 9781441960658
VL - 674
T3 - Advances in Experimental Medicine and Biology
SP - 43
EP - 54
BT - Advances in Experimental Medicine and Biology
ER -