Integrins and signal transduction

Sara Cabodi, Paola Di Stefano, Maria Del Pilar Camacho Leal, Agata Tinnirello, Brigitte Bisaro, Virginia Morello, Laura Damiano, Simona Aramu, Daniele Repetto, Giusy Tornillo, Paola Defilippi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Integrin signaling has a critical function in organizing cells in tissues during both embryonic development and tissue repair. Following their binding to the extracellular ligands, the intracellular signaling pathways triggered by integrins are directed to two major functions: organization of the actin cytoskeleton and regulation of cell behaviour including survival, differentiation and growth. Basic research conducted in the past twelve years has lead to remarkable breakthroughs in this field. Integrins are catalytically inactive and translate positional cues into biochemical signals by direct and/or functional association with intracellular adaptors, cytosolic tyrosine kinases or growth factor and cytokine receptors. The purpose of this chapter is to highlight recent experimental and conceptual advances in integrin signaling with particular emphasis on the ability of integrins to regulate Fak/Src family kinases (SFKs) activation and the cross-talk with soluble growth factors receptors and cytokines.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
Pages43-54
Number of pages12
Volume674
DOIs
Publication statusPublished - 2010

Publication series

NameAdvances in Experimental Medicine and Biology
Volume674
ISSN (Print)00652598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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