Integrins and signal transduction

Sara Cabodi, Paola Di Stefano, Maria Del Pilar Camacho Leal, Agata Tinnirello, Brigitte Bisaro, Virginia Morello, Laura Damiano, Simona Aramu, Daniele Repetto, Giusy Tornillo, Paola Defilippi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Integrin signaling has a critical function in organizing cells in tissues during both embryonic development and tissue repair. Following their binding to the extracellular ligands, the intracellular signaling pathways triggered by integrins are directed to two major functions: organization of the actin cytoskeleton and regulation of cell behaviour including survival, differentiation and growth. Basic research conducted in the past twelve years has lead to remarkable breakthroughs in this field. Integrins are catalytically inactive and translate positional cues into biochemical signals by direct and/or functional association with intracellular adaptors, cytosolic tyrosine kinases or growth factor and cytokine receptors. The purpose of this chapter is to highlight recent experimental and conceptual advances in integrin signaling with particular emphasis on the ability of integrins to regulate Fak/Src family kinases (SFKs) activation and the cross-talk with soluble growth factors receptors and cytokines.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
Pages43-54
Number of pages12
Volume674
DOIs
Publication statusPublished - 2010

Publication series

NameAdvances in Experimental Medicine and Biology
Volume674
ISSN (Print)00652598

Fingerprint

Signal transduction
Integrins
Signal Transduction
Growth Factor Receptors
Tissue
Cytokine Receptors
Aptitude
src-Family Kinases
Actin Cytoskeleton
Protein-Tyrosine Kinases
Embryonic Development
Cues
Actins
Repair
Chemical activation
Cells
Association reactions
Cytokines
Ligands
Growth

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Cabodi, S., Di Stefano, P., Leal, M. D. P. C., Tinnirello, A., Bisaro, B., Morello, V., ... Defilippi, P. (2010). Integrins and signal transduction. In Advances in Experimental Medicine and Biology (Vol. 674, pp. 43-54). (Advances in Experimental Medicine and Biology; Vol. 674). https://doi.org/10.1007/978-1-4419-6066-5_5

Integrins and signal transduction. / Cabodi, Sara; Di Stefano, Paola; Leal, Maria Del Pilar Camacho; Tinnirello, Agata; Bisaro, Brigitte; Morello, Virginia; Damiano, Laura; Aramu, Simona; Repetto, Daniele; Tornillo, Giusy; Defilippi, Paola.

Advances in Experimental Medicine and Biology. Vol. 674 2010. p. 43-54 (Advances in Experimental Medicine and Biology; Vol. 674).

Research output: Chapter in Book/Report/Conference proceedingChapter

Cabodi, S, Di Stefano, P, Leal, MDPC, Tinnirello, A, Bisaro, B, Morello, V, Damiano, L, Aramu, S, Repetto, D, Tornillo, G & Defilippi, P 2010, Integrins and signal transduction. in Advances in Experimental Medicine and Biology. vol. 674, Advances in Experimental Medicine and Biology, vol. 674, pp. 43-54. https://doi.org/10.1007/978-1-4419-6066-5_5
Cabodi S, Di Stefano P, Leal MDPC, Tinnirello A, Bisaro B, Morello V et al. Integrins and signal transduction. In Advances in Experimental Medicine and Biology. Vol. 674. 2010. p. 43-54. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4419-6066-5_5
Cabodi, Sara ; Di Stefano, Paola ; Leal, Maria Del Pilar Camacho ; Tinnirello, Agata ; Bisaro, Brigitte ; Morello, Virginia ; Damiano, Laura ; Aramu, Simona ; Repetto, Daniele ; Tornillo, Giusy ; Defilippi, Paola. / Integrins and signal transduction. Advances in Experimental Medicine and Biology. Vol. 674 2010. pp. 43-54 (Advances in Experimental Medicine and Biology).
@inbook{2cce65d97a9646f0b7299b63b0796a7e,
title = "Integrins and signal transduction",
abstract = "Integrin signaling has a critical function in organizing cells in tissues during both embryonic development and tissue repair. Following their binding to the extracellular ligands, the intracellular signaling pathways triggered by integrins are directed to two major functions: organization of the actin cytoskeleton and regulation of cell behaviour including survival, differentiation and growth. Basic research conducted in the past twelve years has lead to remarkable breakthroughs in this field. Integrins are catalytically inactive and translate positional cues into biochemical signals by direct and/or functional association with intracellular adaptors, cytosolic tyrosine kinases or growth factor and cytokine receptors. The purpose of this chapter is to highlight recent experimental and conceptual advances in integrin signaling with particular emphasis on the ability of integrins to regulate Fak/Src family kinases (SFKs) activation and the cross-talk with soluble growth factors receptors and cytokines.",
author = "Sara Cabodi and {Di Stefano}, Paola and Leal, {Maria Del Pilar Camacho} and Agata Tinnirello and Brigitte Bisaro and Virginia Morello and Laura Damiano and Simona Aramu and Daniele Repetto and Giusy Tornillo and Paola Defilippi",
year = "2010",
doi = "10.1007/978-1-4419-6066-5_5",
language = "English",
isbn = "9781441960658",
volume = "674",
series = "Advances in Experimental Medicine and Biology",
pages = "43--54",
booktitle = "Advances in Experimental Medicine and Biology",

}

TY - CHAP

T1 - Integrins and signal transduction

AU - Cabodi, Sara

AU - Di Stefano, Paola

AU - Leal, Maria Del Pilar Camacho

AU - Tinnirello, Agata

AU - Bisaro, Brigitte

AU - Morello, Virginia

AU - Damiano, Laura

AU - Aramu, Simona

AU - Repetto, Daniele

AU - Tornillo, Giusy

AU - Defilippi, Paola

PY - 2010

Y1 - 2010

N2 - Integrin signaling has a critical function in organizing cells in tissues during both embryonic development and tissue repair. Following their binding to the extracellular ligands, the intracellular signaling pathways triggered by integrins are directed to two major functions: organization of the actin cytoskeleton and regulation of cell behaviour including survival, differentiation and growth. Basic research conducted in the past twelve years has lead to remarkable breakthroughs in this field. Integrins are catalytically inactive and translate positional cues into biochemical signals by direct and/or functional association with intracellular adaptors, cytosolic tyrosine kinases or growth factor and cytokine receptors. The purpose of this chapter is to highlight recent experimental and conceptual advances in integrin signaling with particular emphasis on the ability of integrins to regulate Fak/Src family kinases (SFKs) activation and the cross-talk with soluble growth factors receptors and cytokines.

AB - Integrin signaling has a critical function in organizing cells in tissues during both embryonic development and tissue repair. Following their binding to the extracellular ligands, the intracellular signaling pathways triggered by integrins are directed to two major functions: organization of the actin cytoskeleton and regulation of cell behaviour including survival, differentiation and growth. Basic research conducted in the past twelve years has lead to remarkable breakthroughs in this field. Integrins are catalytically inactive and translate positional cues into biochemical signals by direct and/or functional association with intracellular adaptors, cytosolic tyrosine kinases or growth factor and cytokine receptors. The purpose of this chapter is to highlight recent experimental and conceptual advances in integrin signaling with particular emphasis on the ability of integrins to regulate Fak/Src family kinases (SFKs) activation and the cross-talk with soluble growth factors receptors and cytokines.

UR - http://www.scopus.com/inward/record.url?scp=77954685078&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954685078&partnerID=8YFLogxK

U2 - 10.1007/978-1-4419-6066-5_5

DO - 10.1007/978-1-4419-6066-5_5

M3 - Chapter

C2 - 20549939

AN - SCOPUS:77954685078

SN - 9781441960658

VL - 674

T3 - Advances in Experimental Medicine and Biology

SP - 43

EP - 54

BT - Advances in Experimental Medicine and Biology

ER -