Integrins team up with tyrosine kinase receptors and plexins to control angiogenesis

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: Understanding the role of integrins in the formation of vascular bed is important for designing new therapeutic approaches to ameliorate or inhibit pathological vascularization. Besides regulating cell adhesion and migration, integrins dynamically participate in a network with soluble molecules and their receptors. This study summarizes recent progress in the understanding of the reciprocal interactions between integrins, tyrosine kinase, and semaphorin receptors. RECENT FINDINGS: During angiogenic remodeling, endothelial cells that line blood vessel walls dynamically modify their integrin-mediated adhesive contacts with the surrounding extracellular matrix. During angiogenesis, opposing autocrine and paracrine loops of growth factors and semaphorins regulate endothelial integrin activation and function through tyrosine kinase receptors and the neuropilin/plexins system. Moreover, proangiogenic and antiangiogenic factors can directly bind integrins and regulate endothelial cell behavior. Studies describing these intense research areas are discussed. SUMMARY: Alteration in the balance between the angiogenic growth factors and semaphorins results in an impairment of integrin functions and could account for cardiovascular malformation and structural and functional abnormalities of the tumor vasculature.

Original languageEnglish
Pages (from-to)235-242
Number of pages8
JournalCurrent Opinion in Hematology
Volume15
Issue number3
DOIs
Publication statusPublished - May 2008

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Receptor Protein-Tyrosine Kinases
Integrins
Semaphorins
Blood Vessels
Intercellular Signaling Peptides and Proteins
Neuropilins
Endothelial Cells
Angiogenesis Inducing Agents
Cell Adhesion
Adhesives
Cell Movement
Extracellular Matrix
Cell Line
Research
Neoplasms

Keywords

  • Angiopoietins
  • Autocrine loops
  • Endothelium
  • Semaphorins
  • VEGF

ASJC Scopus subject areas

  • Hematology

Cite this

Integrins team up with tyrosine kinase receptors and plexins to control angiogenesis. / Serini, Guido; Napione, Lucia; Bussolino, Federico.

In: Current Opinion in Hematology, Vol. 15, No. 3, 05.2008, p. 235-242.

Research output: Contribution to journalArticle

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