Intense immunosuppression followed by autologous haematopoietic stem cell transplantation as a therapeutic strategy in aggressive forms of multiple sclerosis

Gianluigi Mancardi, Maria Pia Sormani, Paolo A. Muraro, Giacomo Boffa, Riccardo Saccardi

Research output: Contribution to journalReview article

Abstract

In the majority of relapsing multiple sclerosis patients, the disease can be quite easily controlled by already available, approved therapies. There are, however, some aggressive cases who continue to have clinical and magnetic resonance imaging (MRI) activity in spite of the treatment. These are the cases who may now receive benefit from intense immunosuppression followed by autologous haematopoietic stem cell transplantation (aHSCT). In this review, we describe the method and the rationale of aHSCT, the more recently published studies that demonstrate its efficacy in selected multiple sclerosis cases, the problems related to safety and the transplant-related mortality risk of the procedure. A description of the ideal patient who can take advantage of aHSCT is outlined and, finally, the ongoing studies which are near to completion or are close to starting are briefly reported.

Original languageEnglish
Pages (from-to)245-255
Number of pages11
JournalMultiple Sclerosis Journal
Volume24
Issue number3
DOIs
Publication statusPublished - Mar 1 2018

Keywords

  • bone marrow transplantation
  • Haematopoietic stem cell transplantation
  • intense immunosuppression
  • multiple sclerosis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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