Intensity-based 2-D-3-D registration of cerebral angiograms

John H. Hipwell, Graeme P. Penney, Robert A. McLaughlin, Kawal Rhode, Paul Summers, Tim C. Cox, James V. Byrne, J. Alison Noble, David J. Hawkes

Research output: Contribution to journalArticle

Abstract

We propose a new method for aligning three-dimensional (3-D) magnetic resonance angiography (MRA) with 2-D X-ray digital subtration angiograms (DSA). Our method is developed from our algorithm to register computed tomography volumes to X-ray images based on intensity matching of digitally reconstructed radiographs (DRRs). To make the DSA and DRR more similar, we transform the MRA images to images of the vasculature and set to zero the contralateral side of the MRA to that imaged with DSA. We initialize the search for a match on a user defined circular region of interest. We have tested six similarity measures using both unsegmented MRA and three segmentation variants of the MRA. Registrations were carried out on images of a physical neuro-vascular phantom and images obtained during four neuro-vascular interventions. The most accurate and robust registrations were obtained using the pattern intensity, gradient difference, and gradient correlation similarity measures, when used in conjunction with the most sophisticated MRA segmentations. Using these measures, 95% of the phantom start positions and 80% of the clinical start positions were successfully registered. The lowest root mean square reprojection errors were 1.3 mm (standard deviation 0.6) for the phantom and 1.5 mm (standard deviation 0.9) for the clinical data sets. Finally, we present a novel method for the comparison of similarity measure performance using a technique borrowed from receiver operator characteristic analysis.

Original languageEnglish
Pages (from-to)1417-1426
Number of pages10
JournalIEEE Transactions on Medical Imaging
Volume22
Issue number11
DOIs
Publication statusPublished - Nov 2003

Keywords

  • 2-D-3-D registration
  • Digital subtraction angiography
  • Magnetic resonance angiography
  • Neuro-interventions
  • Similarity measures

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Electrical and Electronic Engineering
  • Computer Science Applications
  • Computational Theory and Mathematics

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  • Cite this

    Hipwell, J. H., Penney, G. P., McLaughlin, R. A., Rhode, K., Summers, P., Cox, T. C., Byrne, J. V., Noble, J. A., & Hawkes, D. J. (2003). Intensity-based 2-D-3-D registration of cerebral angiograms. IEEE Transactions on Medical Imaging, 22(11), 1417-1426. https://doi.org/10.1109/TMI.2003.819283