Intensity modulated radiation therapy and oral mucosa sparing in Head and neck cancer patients: A systematic review on behalf of Italian Association of Radiation Oncology – Head and neck working group

V. De Sanctis, A. Merlotti, F. De Felice, M. Trignani, I. Dell'Oca, L. Lastrucci, M. Molteni, R. Frakulli, F. Bunkheila, A. Bacigalupo, F. Paiar

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Oral mucositis is a common dose-limiting toxicity during radiotherapy with or without chemotherapy in head and neck cancer patients. This potentially severe complication globally worsens quality of life and negatively impacts local control and survival's outcomes. Several studies have been published on feasibility and/or clinical benefit of intensity modulated radiotherapy (IMRT) mucosa-sparing technique. In 2017, the Italian Association of Radiation Oncology Head and Neck Cancer Working Group organized a study group to perform a systematic review. The aim was to verify if practical indications, including dose-constraints and demonstrated clinical benefit, could be proposed for oral mucosa (OM)-sparing IMRT in order to reduce the incidence of severe acute mucositis. Although dose to OM should be reduced as much as possible without compromising target volumes coverage, it is still tricky to firmly state that OM-sparing procedure should be considered the standard of care, especially due to high subjective variability in OM contour.

Original languageEnglish
Pages (from-to)24-30
Number of pages7
JournalCritical Reviews in Oncology/Hematology
Volume139
DOIs
Publication statusPublished - Jul 1 2019

Fingerprint

Radiation Oncology
Mouth Mucosa
Head and Neck Neoplasms
Neck
Radiotherapy
Head
Intensity-Modulated Radiotherapy
Stomatitis
Mucositis
Standard of Care
Mucous Membrane
Quality of Life
Drug Therapy
Survival
Incidence

Keywords

  • Acute mucositis
  • Head neck cancer
  • Intensity modulated radiotherapy
  • Organ sparing

ASJC Scopus subject areas

  • Hematology
  • Oncology

Cite this

Intensity modulated radiation therapy and oral mucosa sparing in Head and neck cancer patients : A systematic review on behalf of Italian Association of Radiation Oncology – Head and neck working group. / De Sanctis, V.; Merlotti, A.; De Felice, F.; Trignani, M.; Dell'Oca, I.; Lastrucci, L.; Molteni, M.; Frakulli, R.; Bunkheila, F.; Bacigalupo, A.; Paiar, F.

In: Critical Reviews in Oncology/Hematology, Vol. 139, 01.07.2019, p. 24-30.

Research output: Contribution to journalReview article

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