Intensive cardiac rehabilitation improves glucometabolic state of non-diabetic patients with recent coronary artery bypass grafting

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Abstract

Background: The aim of this study is to examine the effect of an intensive CR program early after coronary artery bypass grafting on glucometabolic state of non-diabetic patients with CAD. Methods: 60 patients were included in the study. All patients underwent Oral Glucose Tolerance Test (OGTT), Homeostasis Model Assessment (HOMA) Index and Six Minutes Walking Test at baseline and at the end of CR. The patients were then included in a 3-month follow-up program. Results: At baseline 61% of the patients had normal fasting glucose, while after OGTT 28.3% had normal glucose tolerance, 41.6% had impaired glucose tolerance (IGT), and 30.1% had type 2 diabetes mellitus (T2DM). At the end of the CR program the number of patients with T2DM was significantly lower (- 22%, p <0.05) while the number of normal glucose tolerance patients had significantly increased (+ 26%; p <0.05). T2DM and IGT patients showed worse performances at Six Minutes Walking Test than normal glucose tolerance patients at baseline but had a similar improvement after 4. weeks of training. After 3. months follow-up fasting blood glucose, insulin levels and HOMA index were increased compared to 4. week values, but were lower than baseline. Conclusion: OGTT is important to evaluate glucometabolic state of CAD patients. Intensive CR improves glucometabolic state and insulin resistance in CAD patients with impaired glucose metabolism.

Original languageEnglish
Pages (from-to)20-24
Number of pages5
JournalIJC Metabolic and Endocrine
Volume3
DOIs
Publication statusPublished - 2014

Fingerprint

Coronary Artery Bypass
Glucose Tolerance Test
Type 2 Diabetes Mellitus
Glucose
Glucose Intolerance
Walking
Fasting
Homeostasis
Cardiac Rehabilitation
Insulin Resistance
Blood Glucose
Insulin

Keywords

  • Cardiac rehabilitation
  • Coronary artery disease
  • Impaired glucose metabolism
  • Insulin resistance
  • Oral glucose tolerance test

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

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title = "Intensive cardiac rehabilitation improves glucometabolic state of non-diabetic patients with recent coronary artery bypass grafting",
abstract = "Background: The aim of this study is to examine the effect of an intensive CR program early after coronary artery bypass grafting on glucometabolic state of non-diabetic patients with CAD. Methods: 60 patients were included in the study. All patients underwent Oral Glucose Tolerance Test (OGTT), Homeostasis Model Assessment (HOMA) Index and Six Minutes Walking Test at baseline and at the end of CR. The patients were then included in a 3-month follow-up program. Results: At baseline 61{\%} of the patients had normal fasting glucose, while after OGTT 28.3{\%} had normal glucose tolerance, 41.6{\%} had impaired glucose tolerance (IGT), and 30.1{\%} had type 2 diabetes mellitus (T2DM). At the end of the CR program the number of patients with T2DM was significantly lower (- 22{\%}, p <0.05) while the number of normal glucose tolerance patients had significantly increased (+ 26{\%}; p <0.05). T2DM and IGT patients showed worse performances at Six Minutes Walking Test than normal glucose tolerance patients at baseline but had a similar improvement after 4. weeks of training. After 3. months follow-up fasting blood glucose, insulin levels and HOMA index were increased compared to 4. week values, but were lower than baseline. Conclusion: OGTT is important to evaluate glucometabolic state of CAD patients. Intensive CR improves glucometabolic state and insulin resistance in CAD patients with impaired glucose metabolism.",
keywords = "Cardiac rehabilitation, Coronary artery disease, Impaired glucose metabolism, Insulin resistance, Oral glucose tolerance test",
author = "Rosalba Massaro and Giuseppe Caminiti and Arianna Tulli and Chiara Fossati and Maurizio Volterrani and Massimo Fini and Rosano, {Giuseppe M C}",
year = "2014",
doi = "10.1016/j.ijcme.2014.04.001",
language = "English",
volume = "3",
pages = "20--24",
journal = "IJC Metabolic and Endocrine",
issn = "2214-7624",
publisher = "Elsevier Scientific Publishers Ireland",

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T1 - Intensive cardiac rehabilitation improves glucometabolic state of non-diabetic patients with recent coronary artery bypass grafting

AU - Massaro, Rosalba

AU - Caminiti, Giuseppe

AU - Tulli, Arianna

AU - Fossati, Chiara

AU - Volterrani, Maurizio

AU - Fini, Massimo

AU - Rosano, Giuseppe M C

PY - 2014

Y1 - 2014

N2 - Background: The aim of this study is to examine the effect of an intensive CR program early after coronary artery bypass grafting on glucometabolic state of non-diabetic patients with CAD. Methods: 60 patients were included in the study. All patients underwent Oral Glucose Tolerance Test (OGTT), Homeostasis Model Assessment (HOMA) Index and Six Minutes Walking Test at baseline and at the end of CR. The patients were then included in a 3-month follow-up program. Results: At baseline 61% of the patients had normal fasting glucose, while after OGTT 28.3% had normal glucose tolerance, 41.6% had impaired glucose tolerance (IGT), and 30.1% had type 2 diabetes mellitus (T2DM). At the end of the CR program the number of patients with T2DM was significantly lower (- 22%, p <0.05) while the number of normal glucose tolerance patients had significantly increased (+ 26%; p <0.05). T2DM and IGT patients showed worse performances at Six Minutes Walking Test than normal glucose tolerance patients at baseline but had a similar improvement after 4. weeks of training. After 3. months follow-up fasting blood glucose, insulin levels and HOMA index were increased compared to 4. week values, but were lower than baseline. Conclusion: OGTT is important to evaluate glucometabolic state of CAD patients. Intensive CR improves glucometabolic state and insulin resistance in CAD patients with impaired glucose metabolism.

AB - Background: The aim of this study is to examine the effect of an intensive CR program early after coronary artery bypass grafting on glucometabolic state of non-diabetic patients with CAD. Methods: 60 patients were included in the study. All patients underwent Oral Glucose Tolerance Test (OGTT), Homeostasis Model Assessment (HOMA) Index and Six Minutes Walking Test at baseline and at the end of CR. The patients were then included in a 3-month follow-up program. Results: At baseline 61% of the patients had normal fasting glucose, while after OGTT 28.3% had normal glucose tolerance, 41.6% had impaired glucose tolerance (IGT), and 30.1% had type 2 diabetes mellitus (T2DM). At the end of the CR program the number of patients with T2DM was significantly lower (- 22%, p <0.05) while the number of normal glucose tolerance patients had significantly increased (+ 26%; p <0.05). T2DM and IGT patients showed worse performances at Six Minutes Walking Test than normal glucose tolerance patients at baseline but had a similar improvement after 4. weeks of training. After 3. months follow-up fasting blood glucose, insulin levels and HOMA index were increased compared to 4. week values, but were lower than baseline. Conclusion: OGTT is important to evaluate glucometabolic state of CAD patients. Intensive CR improves glucometabolic state and insulin resistance in CAD patients with impaired glucose metabolism.

KW - Cardiac rehabilitation

KW - Coronary artery disease

KW - Impaired glucose metabolism

KW - Insulin resistance

KW - Oral glucose tolerance test

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