Intensive care unit admission in children with malignant or nonmalignant disease: Incidence, outcome, and prognostic factors: A single-center experience

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Objective: To investigate pediatric intensive care unit (PICU) admission in children with malignant and nonmalignant diseases who developed life-threatening complications.

Patients and Methods: Between 1999 and 2010, of the 1278 eligible pediatric patients treated for a malignant or nonmalignant disease, 54 were admitted to the PICU for respiratory distress (40.7%), neurological events (33.3%), severe sepsis (14.8%), and organ failure (11.2%).

Results: Rate of PICU admission was 4.2%, with a 2-year cumulative incidence of 4.5%. Risk factors associated with higher cumulative incidence of PICU admission were older age at study entry (P=0.003), nonmalignant underlying disease (P=0.015), and hematopoietic stem cell transplantation (P

Conclusions: Nonmalignant disease and use of alternative hematopoietic stem cell transplantation were associated with higher risk of PICU admission. Close cooperation between hematologists and intensivists and definition of criteria for PICU admission and discharge contributed to increase in survival of these patients.

Original languageEnglish
Pages (from-to)e403-e409
JournalJournal of Pediatric Hematology/Oncology
Issue number7
Publication statusPublished - Oct 8 2014



  • Hematopoietic stem cell transplantation
  • Malignant or nonmalignant disease
  • Mechanical ventilation
  • Pediatric intensive care unit

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology

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