Inter-day glycemic variability assessed by continuous glucose monitoring in insulin-treated type 2 diabetes patients on hemodialysis

Marco Mirani, Cesare Berra, Silvia Finazzi, Albania Calvetta, Maria Grazia Radaelli, Flavia Favareto, Giorgio Graziani, Salvatore Badalamenti

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: Type 2 diabetes patients on chronic hemodialysis have a high prevalence of cardiovascular complications and often show a poor glycemic control. Single-spot glycemic measurements are not always meaningful, and the hemoglobin A1c (HbA1c) value does not reflect short-term variations in glucose metabolism in this patient category. Therefore, to better understand their metabolic balance, we studied a group of diabetes patients on hemodialysis by a continuous glucose monitoring (CGM) system. Methods: Twelve insulin-treated type 2 diabetes patients on hemodialysis were studied by a microdialysis-based subcutaneous glucose sensor over a period of 2 days, including the dialysis day (HD) and the following inter-dialytic period ("free" day [FD]). Results: The mean 24-h glycemic value, the mean amplitude of glucose excursions, and the SD of mean glucose were significantly higher in the HD than the FD (186 ±50 vs. 154 ± 25 mg/dL, P

Original languageEnglish
Pages (from-to)749-753
Number of pages5
JournalDiabetes Technology and Therapeutics
Volume12
Issue number10
DOIs
Publication statusPublished - Oct 1 2010

Fingerprint

Type 2 Diabetes Mellitus
Renal Dialysis
Insulin
Glucose
Microdialysis
Dialysis
Hemoglobins

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Medical Laboratory Technology

Cite this

Inter-day glycemic variability assessed by continuous glucose monitoring in insulin-treated type 2 diabetes patients on hemodialysis. / Mirani, Marco; Berra, Cesare; Finazzi, Silvia; Calvetta, Albania; Radaelli, Maria Grazia; Favareto, Flavia; Graziani, Giorgio; Badalamenti, Salvatore.

In: Diabetes Technology and Therapeutics, Vol. 12, No. 10, 01.10.2010, p. 749-753.

Research output: Contribution to journalArticle

@article{acbb71bda6ed4b6da4c5f5e4deee8100,
title = "Inter-day glycemic variability assessed by continuous glucose monitoring in insulin-treated type 2 diabetes patients on hemodialysis",
abstract = "Background: Type 2 diabetes patients on chronic hemodialysis have a high prevalence of cardiovascular complications and often show a poor glycemic control. Single-spot glycemic measurements are not always meaningful, and the hemoglobin A1c (HbA1c) value does not reflect short-term variations in glucose metabolism in this patient category. Therefore, to better understand their metabolic balance, we studied a group of diabetes patients on hemodialysis by a continuous glucose monitoring (CGM) system. Methods: Twelve insulin-treated type 2 diabetes patients on hemodialysis were studied by a microdialysis-based subcutaneous glucose sensor over a period of 2 days, including the dialysis day (HD) and the following inter-dialytic period ({"}free{"} day [FD]). Results: The mean 24-h glycemic value, the mean amplitude of glucose excursions, and the SD of mean glucose were significantly higher in the HD than the FD (186 ±50 vs. 154 ± 25 mg/dL, P",
author = "Marco Mirani and Cesare Berra and Silvia Finazzi and Albania Calvetta and Radaelli, {Maria Grazia} and Flavia Favareto and Giorgio Graziani and Salvatore Badalamenti",
year = "2010",
month = "10",
day = "1",
doi = "10.1089/dia.2010.0052",
language = "English",
volume = "12",
pages = "749--753",
journal = "Diabetes Technology and Therapeutics",
issn = "1520-9156",
publisher = "Mary Ann Liebert Inc.",
number = "10",

}

TY - JOUR

T1 - Inter-day glycemic variability assessed by continuous glucose monitoring in insulin-treated type 2 diabetes patients on hemodialysis

AU - Mirani, Marco

AU - Berra, Cesare

AU - Finazzi, Silvia

AU - Calvetta, Albania

AU - Radaelli, Maria Grazia

AU - Favareto, Flavia

AU - Graziani, Giorgio

AU - Badalamenti, Salvatore

PY - 2010/10/1

Y1 - 2010/10/1

N2 - Background: Type 2 diabetes patients on chronic hemodialysis have a high prevalence of cardiovascular complications and often show a poor glycemic control. Single-spot glycemic measurements are not always meaningful, and the hemoglobin A1c (HbA1c) value does not reflect short-term variations in glucose metabolism in this patient category. Therefore, to better understand their metabolic balance, we studied a group of diabetes patients on hemodialysis by a continuous glucose monitoring (CGM) system. Methods: Twelve insulin-treated type 2 diabetes patients on hemodialysis were studied by a microdialysis-based subcutaneous glucose sensor over a period of 2 days, including the dialysis day (HD) and the following inter-dialytic period ("free" day [FD]). Results: The mean 24-h glycemic value, the mean amplitude of glucose excursions, and the SD of mean glucose were significantly higher in the HD than the FD (186 ±50 vs. 154 ± 25 mg/dL, P

AB - Background: Type 2 diabetes patients on chronic hemodialysis have a high prevalence of cardiovascular complications and often show a poor glycemic control. Single-spot glycemic measurements are not always meaningful, and the hemoglobin A1c (HbA1c) value does not reflect short-term variations in glucose metabolism in this patient category. Therefore, to better understand their metabolic balance, we studied a group of diabetes patients on hemodialysis by a continuous glucose monitoring (CGM) system. Methods: Twelve insulin-treated type 2 diabetes patients on hemodialysis were studied by a microdialysis-based subcutaneous glucose sensor over a period of 2 days, including the dialysis day (HD) and the following inter-dialytic period ("free" day [FD]). Results: The mean 24-h glycemic value, the mean amplitude of glucose excursions, and the SD of mean glucose were significantly higher in the HD than the FD (186 ±50 vs. 154 ± 25 mg/dL, P

UR - http://www.scopus.com/inward/record.url?scp=77957943049&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957943049&partnerID=8YFLogxK

U2 - 10.1089/dia.2010.0052

DO - 10.1089/dia.2010.0052

M3 - Article

VL - 12

SP - 749

EP - 753

JO - Diabetes Technology and Therapeutics

JF - Diabetes Technology and Therapeutics

SN - 1520-9156

IS - 10

ER -