Inter-day glycemic variability assessed by continuous glucose monitoring in insulin-treated type 2 diabetes patients on hemodialysis

Marco Mirani, Cesare Berra, Silvia Finazzi, Albania Calvetta, Maria Grazia Radaelli, Flavia Favareto, Giorgio Graziani, Salvatore Badalamenti

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Type 2 diabetes patients on chronic hemodialysis have a high prevalence of cardiovascular complications and often show a poor glycemic control. Single-spot glycemic measurements are not always meaningful, and the hemoglobin A1c (HbA1c) value does not reflect short-term variations in glucose metabolism in this patient category. Therefore, to better understand their metabolic balance, we studied a group of diabetes patients on hemodialysis by a continuous glucose monitoring (CGM) system. Methods: Twelve insulin-treated type 2 diabetes patients on hemodialysis were studied by a microdialysis-based subcutaneous glucose sensor over a period of 2 days, including the dialysis day (HD) and the following inter-dialytic period ("free" day [FD]). Results: The mean 24-h glycemic value, the mean amplitude of glucose excursions, and the SD of mean glucose were significantly higher in the HD than the FD (186 ±50 vs. 154 ± 25 mg/dL, P

Original languageEnglish
Pages (from-to)749-753
Number of pages5
JournalDiabetes Technology and Therapeutics
Volume12
Issue number10
DOIs
Publication statusPublished - Oct 1 2010

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Medical Laboratory Technology

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