Inter-hemispheric asymmetry of cerebral flow velocities during generalized spike-wave discharges

Roberto De Simone, Fabio Placidi, Marina Diomedi, Maria Grazia Marciani, Mauro Silvestrini

Research output: Contribution to journalArticlepeer-review


The aim of this study was to verify the symmetry of cerebral blood flow changes during the generalized spike-wave discharges of typical absence seizures. A recording of mean flow velocity in the left and right middle cerebral arteries and of electroencephalographic activity was performed simultaneously in two subjects with multiple daily absence seizures. A total of 12 generalized spike-wave discharges were recorded. Mean flow velocities showed a significant increase during the discharges with respect to baseline. The increase of flow velocity started simultaneously or a few seconds before the discharges. In 91.6% of all recordings, the percentage increase of mean flow velocity was significantly higher in the left than in the right side (7.03% ± 3.3 vs 5.14% ± 3.3; p <0.1). The extent of the following decrease of flow velocity was also significantly greater in the left than in the right side (-16.91% ± 8.1 vs -14.07% ± 8.3; p <0.01). These findings show an inter-hemispheric asymmetry in cerebral blood flow during generalized spike-wave discharges in two patients with absence seizures. Transcranial Doppler ultrasonography promises to be an interesting approach to detect rapid changes in cerebral hemispheric activity not otherwise recognizable.

Original languageEnglish
Pages (from-to)1191-1194
Number of pages4
JournalJournal of Neurology
Issue number9
Publication statusPublished - 2002


  • Absence
  • Cerebral activation
  • Cerebral blood flow
  • Electroencephalography
  • Transcranial Doppler ultrasonography

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


Dive into the research topics of 'Inter-hemispheric asymmetry of cerebral flow velocities during generalized spike-wave discharges'. Together they form a unique fingerprint.

Cite this