Abstract
The aim of this study was to verify the symmetry of cerebral blood flow changes during the generalized spike-wave discharges of typical absence seizures. A recording of mean flow velocity in the left and right middle cerebral arteries and of electroencephalographic activity was performed simultaneously in two subjects with multiple daily absence seizures. A total of 12 generalized spike-wave discharges were recorded. Mean flow velocities showed a significant increase during the discharges with respect to baseline. The increase of flow velocity started simultaneously or a few seconds before the discharges. In 91.6% of all recordings, the percentage increase of mean flow velocity was significantly higher in the left than in the right side (7.03% ± 3.3 vs 5.14% ± 3.3; p <0.1). The extent of the following decrease of flow velocity was also significantly greater in the left than in the right side (-16.91% ± 8.1 vs -14.07% ± 8.3; p <0.01). These findings show an inter-hemispheric asymmetry in cerebral blood flow during generalized spike-wave discharges in two patients with absence seizures. Transcranial Doppler ultrasonography promises to be an interesting approach to detect rapid changes in cerebral hemispheric activity not otherwise recognizable.
| Original language | English |
|---|---|
| Pages (from-to) | 1191-1194 |
| Number of pages | 4 |
| Journal | Journal of Neurology |
| Volume | 249 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2002 |
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Keywords
- Absence
- Cerebral activation
- Cerebral blood flow
- Electroencephalography
- Transcranial Doppler ultrasonography
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
Cite this
Inter-hemispheric asymmetry of cerebral flow velocities during generalized spike-wave discharges. / De Simone, Roberto; Placidi, Fabio; Diomedi, Marina; Marciani, Maria Grazia; Silvestrini, Mauro.
In: Journal of Neurology, Vol. 249, No. 9, 2002, p. 1191-1194.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inter-hemispheric asymmetry of cerebral flow velocities during generalized spike-wave discharges
AU - De Simone, Roberto
AU - Placidi, Fabio
AU - Diomedi, Marina
AU - Marciani, Maria Grazia
AU - Silvestrini, Mauro
PY - 2002
Y1 - 2002
N2 - The aim of this study was to verify the symmetry of cerebral blood flow changes during the generalized spike-wave discharges of typical absence seizures. A recording of mean flow velocity in the left and right middle cerebral arteries and of electroencephalographic activity was performed simultaneously in two subjects with multiple daily absence seizures. A total of 12 generalized spike-wave discharges were recorded. Mean flow velocities showed a significant increase during the discharges with respect to baseline. The increase of flow velocity started simultaneously or a few seconds before the discharges. In 91.6% of all recordings, the percentage increase of mean flow velocity was significantly higher in the left than in the right side (7.03% ± 3.3 vs 5.14% ± 3.3; p <0.1). The extent of the following decrease of flow velocity was also significantly greater in the left than in the right side (-16.91% ± 8.1 vs -14.07% ± 8.3; p <0.01). These findings show an inter-hemispheric asymmetry in cerebral blood flow during generalized spike-wave discharges in two patients with absence seizures. Transcranial Doppler ultrasonography promises to be an interesting approach to detect rapid changes in cerebral hemispheric activity not otherwise recognizable.
AB - The aim of this study was to verify the symmetry of cerebral blood flow changes during the generalized spike-wave discharges of typical absence seizures. A recording of mean flow velocity in the left and right middle cerebral arteries and of electroencephalographic activity was performed simultaneously in two subjects with multiple daily absence seizures. A total of 12 generalized spike-wave discharges were recorded. Mean flow velocities showed a significant increase during the discharges with respect to baseline. The increase of flow velocity started simultaneously or a few seconds before the discharges. In 91.6% of all recordings, the percentage increase of mean flow velocity was significantly higher in the left than in the right side (7.03% ± 3.3 vs 5.14% ± 3.3; p <0.1). The extent of the following decrease of flow velocity was also significantly greater in the left than in the right side (-16.91% ± 8.1 vs -14.07% ± 8.3; p <0.01). These findings show an inter-hemispheric asymmetry in cerebral blood flow during generalized spike-wave discharges in two patients with absence seizures. Transcranial Doppler ultrasonography promises to be an interesting approach to detect rapid changes in cerebral hemispheric activity not otherwise recognizable.
KW - Absence
KW - Cerebral activation
KW - Cerebral blood flow
KW - Electroencephalography
KW - Transcranial Doppler ultrasonography
UR - http://www.scopus.com/inward/record.url?scp=0036037564&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036037564&partnerID=8YFLogxK
U2 - 10.1007/s00415-002-0803-4
DO - 10.1007/s00415-002-0803-4
M3 - Article
C2 - 12242537
AN - SCOPUS:0036037564
VL - 249
SP - 1191
EP - 1194
JO - Journal of Neurology
JF - Journal of Neurology
SN - 0340-5354
IS - 9
ER -