Interaction between calcineurin inhibitors and IL-28B rs12979860 C>T polymorphism and response to treatment for post-transplant recurrent hepatitis C

Davide Bitetto, Tullia De Feo, Martina Mantovani, Edmondo Falleti, Carlo Fabris, Luca Saverio Belli, Stefano Fagiuoli, Patrizia Burra, Giuseppe Piccolo, Maria Francesca Donato, Pierluigi Toniutto, Sara Cmet, Annarosa Cussigh, Raffaella Viganò, Aldo Airoldi, Luisa Pasulo, Maria Colpanij, Eleonora De Martin, Martina Gambato, Cristina Rigamonti

Research output: Contribution to journalArticle

Abstract

Background: The impact of calcineurin inhibitors on achievement of sustained virological response to antiviral therapy for post-transplant recurrent hepatitis C is controversial. This study aimed at investigating the interactions between calcineurin inhibitors and interleukin-28B (IL-28B) gene polymorphisms and sustained virological response. Methods: Retrospective study of 147 liver transplant recipients with recurrent hepatitis C, who received 48 weeks of peg-interferon-α (N=113) or standard interferon (N=34), in association with ribavirin. Cyclosporine and tacrolimus were administered in 68 and 79 patients, respectively. IL-28B rs12979860 allele frequency was assessed in both donors and recipients. Results: Overall, 57 patients (38.8%) obtained sustained virological response; no difference was found between cyclosporine and tacrolimus-treated patients (42.6% vs. 35.4%, p=0.371). Recipient and donor IL-28B genotypic frequencies were C/C=30.6%, C/T=51.7%, T/T=17.7% and C/C=44.9%, C/T=50.3%, T/T=4.8%, respectively. Combining donor and recipient alleles, response rates decreased from cyclosporine-treated patients carrying ≤1 T allele (56.1%) to tacrolimus-treated patients carrying ≤1 T allele (44.7%) to patients carrying ≥2 T alleles (25.0%, p=0.0009). Conclusions: Donor and recipient rs12979860 alleles synergistically influence sustained virological response rate to antiviral treatment for recurrent hepatitis C. In patients carrying

Original languageEnglish
Pages (from-to)927-932
Number of pages6
JournalDigestive and Liver Disease
Volume45
Issue number11
DOIs
Publication statusPublished - Nov 2013

Keywords

  • Antiviral therapy
  • Calcineurin inhibitors
  • Chronic hepatitis
  • Interleukin-28B polymorphisms
  • Liver transplantation

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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    Bitetto, D., De Feo, T., Mantovani, M., Falleti, E., Fabris, C., Belli, L. S., Fagiuoli, S., Burra, P., Piccolo, G., Donato, M. F., Toniutto, P., Cmet, S., Cussigh, A., Viganò, R., Airoldi, A., Pasulo, L., Colpanij, M., De Martin, E., Gambato, M., & Rigamonti, C. (2013). Interaction between calcineurin inhibitors and IL-28B rs12979860 C>T polymorphism and response to treatment for post-transplant recurrent hepatitis C. Digestive and Liver Disease, 45(11), 927-932. https://doi.org/10.1016/j.dld.2013.04.006