Interaction between Hb Hasharon and α-thalassemia: an approach to the problem of the number of human α loci

P. Pich, G. Saglio, C. Camaschella, O. David, M. A. Vasino, G. Ricco, U. Mazza

Research output: Contribution to journalArticlepeer-review

Abstract

The authors report the case of an Italian infant girl from Polesine (Po delta region in northern Italy) who was heterozygous for Hb Hasharon and α-thalassemia, did not synthesize any normal HbA, and had 3% HbH on electrophoresis. Hematologic and biosynthetic studies on Hb Hasharon carriers of the propositus' family suggest the possibility that the Hb Hasharon gene is linked to an α-thalassemia gene. On the other hand, in the Askenazy carriers of Hb Hasharon, Hb Hasharon is probably linked to a normal α gene. In comparing Hb Hasharon's behavior with that of other α variants, particularly HbG Philadelphia, frequent recombinations between α structural genes were suggested. The possible identity between the single α locus and the α 2-thalassemia genotype is discussed.

Original languageEnglish
Pages (from-to)339-346
Number of pages8
JournalBlood
Volume51
Issue number2
Publication statusPublished - 1978

ASJC Scopus subject areas

  • Hematology

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