Interaction between hormone-dependent and hormone-independent human breast cancer cells

V. Cappelletti, C. Ruedl, G. Granata, D. Coradini, G. Del Bino, G. Di Fronzo

Research output: Contribution to journalArticlepeer-review

Abstract

We developed two different models based on in vitro co-culture of hormone-dependent and hormone-independent cell lines to simulate the cell population heterogeneity of human breast cancer tumours. Oestrogen-dependent (MCF-7, ZR 75.1) and oestrogen-independent cell lines (MDAMB-231 BT-20) were grown under serum-free conditions. Co-culture of hormone-dependent and hormone-independent cell lines resulted in an increased cell yield compared to single cell cultures carried out at the same seeding ratios. Such an increase was not affected by addition of oestradiol and single growth factors (EGF, bFGF and IGF-I). These results allow us to conclude that in a heterogeneous cell population like human breast tumours, interaction between hormone-dependent and hormone-independent cell lines may result in a complex regulation of cell growth.

Original languageEnglish
Pages (from-to)1154-1157
Number of pages4
JournalEuropean Journal of Cancer and Clinical Oncology
Volume27
Issue number9
DOIs
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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