Interaction between parathyroid hormone and the Charlson comorbidity index on survival of incident haemodialysis patients

Luigi Francesco Morrone, Sandro Mazzaferro, Domenico Russo, Filippo Aucella, Mario Cozzolino, Maria Grazia Facchini, Andrea Galfr, Fabio Malberti, Maria Cristina Mereu, Maurizio Nordio, Giovanni Pertosa, Domenico Santoro

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Haemodialysis patients are ageing and have with a high rate of comorbidities. The impact of this novel clinical setting on intact parathyroid hormone (iPTH) is not well established.Methods. For this observational, prospective multicentre cohort study, incident haemodialysis patients were recruited in 40 Italian centres and followed up for a mean period of 18 ± 6.7 months. Clinical characteristics and biochemistry were recorded at baseline. Comorbid conditions were scored by the Charlson comorbidity index (CCI).Results. Data of 411 patients (mean age: 66.5 ± 14.8 years; 17.3 >80 years old) were recorded. The mean CCI was 4.17 ± 2.8. In patients with CCI >0, an inverse correlation was observed between CCI (excluding age) and iPTH (P = 0.00002). Independently of CCI, patients with iPTH

Original languageEnglish
Pages (from-to)2859-2865
Number of pages7
JournalNephrology Dialysis Transplantation
Volume24
Issue number9
DOIs
Publication statusPublished - Sep 2009

Keywords

  • Charlson index
  • Elderly
  • Incident ESRD patients
  • Intact parathyroid hormone
  • Survival

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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