The practice of monitoring serum phenytoin levels has proven invaluable in the clinical management of patients with epilepsy. Genetic and environmental factors can influence considerably the rate of metabolism of the drug, contributing to large interindividual differences in the serum levels associated with a fixed dosage regimen. Variations of steady state levels within individuals receiving the same dose of the drug also occur and are usually explained as the result of non-compliance, differences in bioavailability or interactions with other antiepileptic drugs. The possibility of interaction with non-antiepileptic drugs needs to be considered also. The present report describes an increase in serum phenytoin levels associated with concurrent administration of imipramine in 2 epileptic patients, aged 29 and 34 yr.
|Number of pages||2|
|Journal||British Journal of Clinical Pharmacology|
|Publication status||Published - 1977|
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)