Interaction between phenytoin and imipramine

E. Perucca, A. Richens

Research output: Contribution to journalArticlepeer-review


The practice of monitoring serum phenytoin levels has proven invaluable in the clinical management of patients with epilepsy. Genetic and environmental factors can influence considerably the rate of metabolism of the drug, contributing to large interindividual differences in the serum levels associated with a fixed dosage regimen. Variations of steady state levels within individuals receiving the same dose of the drug also occur and are usually explained as the result of non-compliance, differences in bioavailability or interactions with other antiepileptic drugs. The possibility of interaction with non-antiepileptic drugs needs to be considered also. The present report describes an increase in serum phenytoin levels associated with concurrent administration of imipramine in 2 epileptic patients, aged 29 and 34 yr.

Original languageEnglish
Pages (from-to)485-486
Number of pages2
JournalBritish Journal of Clinical Pharmacology
Issue number4
Publication statusPublished - 1977

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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