Interaction between platelets and lupus anticoagulant

M. Galli, S. Cortelazzo, P. Viero, G. Finazzi, G. De Gaetano, T. Barbui

Research output: Contribution to journalArticlepeer-review


10 consecutive patients fulfilled the diagnostic criteria for lupus anticoagulant. 4 had concomitant systemic lupus erythematosus, 1 Waldenstrom's disease and 5 had no apparent underlying disease. Only the case with Waldenstrom's disease presented a bleeding tendency, with bleeding time > 20 min; the others had a history of thrombotic complications. A defect of platelet aggregation induced by ADP, apinephrine, collagen and arachidonic acid was documented in the Waldenstrom's disease case whose lupus anticoagulant was an IgM. In the others, lupus anticoagulant, identified as IgG immunoglobulins, produced no aggregation abnormalities. However, beta-thromboglobulin levels in platelets, plasma and urine were consistent with a pattern of platelet activation in all cases. IgG immunoglobulins separated from sera of 6 patients showed lupus anticoagulant activity, with no effects on platelet aggregation of normal platelet-rich plasma, but they induced secretion of beta-thromboglobulin from normal platelets.

Original languageEnglish
Pages (from-to)88-94
Number of pages7
JournalEuropean Journal of Haematology
Issue number1
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Hematology


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