TY - JOUR
T1 - Interaction between selected environmental factors and familial propensity for colon cancer
AU - La Vecchia, C.
AU - Callus, S.
AU - Talamini, R.
AU - Decarli, A.
AU - Negri, E.
AU - Franceschi, S.
PY - 1999
Y1 - 1999
N2 - Using data of a case-control study conducted in Italy between 1992 and 1996 on 1225 cases of colon cancer and 4154 controls, we have evaluated the effect of selected established risk factors in subjects with, and in those without, familial propensity (134 cases, 146 controls); there were non- significant associations between education and meal frequency and colon cancer risk. Physical activity, high energy and low vegetable intake were significantly related to colon cancer risk in subjects without familial predisposition, but showed no relationship in those with family history of colorectal cancer: the ORs were 1.1 for the lowest level of physical activity, 0.7 for the highest tertile of energy intake, and 1.0 for the lowest one of vegetable intake. These findings would suggest that genetic predisposition can make the influence of environmental factors for defining the risk of colon cancer weak and/or difficult to estimate.
AB - Using data of a case-control study conducted in Italy between 1992 and 1996 on 1225 cases of colon cancer and 4154 controls, we have evaluated the effect of selected established risk factors in subjects with, and in those without, familial propensity (134 cases, 146 controls); there were non- significant associations between education and meal frequency and colon cancer risk. Physical activity, high energy and low vegetable intake were significantly related to colon cancer risk in subjects without familial predisposition, but showed no relationship in those with family history of colorectal cancer: the ORs were 1.1 for the lowest level of physical activity, 0.7 for the highest tertile of energy intake, and 1.0 for the lowest one of vegetable intake. These findings would suggest that genetic predisposition can make the influence of environmental factors for defining the risk of colon cancer weak and/or difficult to estimate.
KW - Case-control studies
KW - Colon cancer
KW - Diet
KW - Familial cancers
KW - Interaction
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M3 - Article
C2 - 10335461
AN - SCOPUS:0032921648
VL - 8
SP - 147
EP - 150
JO - European Journal of Cancer Prevention
JF - European Journal of Cancer Prevention
SN - 0959-8278
IS - 2
ER -