Interaction between SERTPR and stressful life events on response to antidepressant treatment

Laura Mandelli, Elena Marino, Adele Pirovano, Raffaella Calati, Raffaella Zanardi, Cristina Colombo, Alessandro Serretti

Research output: Contribution to journalArticlepeer-review


A polymorphism within the serotonin transporter gene (SERTPR) has been repeatedly associated to mood disorders and response to SSRIs treatment. Recent evidence suggested that influence of genetic effect of SERTPR might be modulated by stress, particularly as regard the development of anxious-depressive symptoms. Nevertheless, there is no information about the role of stressors as potential modulator of SERTPR effects on depressive outcome during pharmacological treatment. In a sample of 159 mood disorder patients treated with fluvoxamine, we found stressors preceding the onset of the illness significantly influencing the genetic effect exerted by SERTPR on response after 6 weeks of treatment. This preliminary finding supports the idea of complex interaction between biological and environmental factors underlying the efficacy of biological treatments, other than liability for mood disorders. Nevertheless, many limitations characterize the present investigation and well-funded studies on larger samples are required.

Original languageEnglish
Pages (from-to)64-67
Number of pages4
JournalEuropean Neuropsychopharmacology
Issue number1
Publication statusPublished - Jan 2009


  • Gene x environment interaction
  • Response to SSRIs
  • Stressful life events

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)
  • Biological Psychiatry
  • Neurology
  • Pharmacology


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