Interaction between the APOE ε4 allele and the APH-1b c + 651T > G SNP in Alzheimer's disease

Maura Poli, Luisa Benerini Gatta, Carlo Lovati, Claudio Mariani, Daniela Galimberti, Elio Scarpini, Ida Biunno, Massimo Musicco, Roberto Dominici, Alberto Albertini, Dario Finazzi

Research output: Contribution to journalArticle

Abstract

The γ-secretase complex is a multimeric aspartyl protease which plays a pivotal role in the production of amyloid β-peptide, the main component of senile plaques in Alzheimer's disease (AD). APH-1a and APH-1b have been recently identified as important subunits of the γ-secretase complex. We previously studied sequence variations in both genes and their association with AD in a small Italian population. The rare polymorphism c + 651T > G in APH-1b showed a possible interaction with the Apolipoprotein E (APOE) ε4 allele in the AD population sample. We extended our genetic analysis to 449 AD patients and 435 controls and, in AD cases, we found a significant interaction (P = 0.001) between the allelic variants in the two genes, resulting in a marked increase of the relative risk for AD (OR = 28.6). Despite the amino acid substitution does not seem to modify either the intracellular localization or the half-life of APH-1b protein, these data suggest that a cooperative mechanism involving APOE and APH-1b plays a role in the susceptibility to develop AD.

Original languageEnglish
Pages (from-to)1494-1501
Number of pages8
JournalNeurobiology of Aging
Volume29
Issue number10
DOIs
Publication statusPublished - Oct 2008

Keywords

  • β-Amyloid
  • γ-Secretase
  • Alzheimer's disease
  • APH-1
  • APOE
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

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    Poli, M., Gatta, L. B., Lovati, C., Mariani, C., Galimberti, D., Scarpini, E., Biunno, I., Musicco, M., Dominici, R., Albertini, A., & Finazzi, D. (2008). Interaction between the APOE ε4 allele and the APH-1b c + 651T > G SNP in Alzheimer's disease. Neurobiology of Aging, 29(10), 1494-1501. https://doi.org/10.1016/j.neurobiolaging.2007.03.019