Interaction of (+) amphetamine with cerebral dopaminergic neurones in two strains of mice, that show different temperature responses to this drug

S. Caccia, G. Cecchetti, S. Garattini, A. Jori

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

(+) Amphetamine sulphate elicits a dose dependent hyperthermia in NMRI mice but its does not significantly increase the body temperature of C3H mice. When low doses of (+) amphetamine are given, the body temperature of C3H mice decreases. (+) Amphetamine decreases the noradrenaline concentration in the brainstem and increases the homovanillic acid concentration (HVA) in the striatum of NMRI mice, but only slightly reduces the noradrenaline concentration and does not changes the HVA concentration in the brains of C3H mice. The 2 strains appear to show a difference in the metabolism of dopamine in the striatum. The rates at which dopamine disappears from the tissue after blocking catecholamine synthesis with α methyltyrosine and the rates at which HVA accumulates after blocking the active transport of this metabolite out of the brain with probenecid suggest that the turnover of dopamine is lower in C3H mice than in NMRI mice.

Original languageEnglish
Title of host publicationBRIT.J.PHARMACOL.
Pages400-406
Number of pages7
Volume49
Edition3
Publication statusPublished - 1973

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Interaction of (+) amphetamine with cerebral dopaminergic neurones in two strains of mice, that show different temperature responses to this drug'. Together they form a unique fingerprint.

Cite this