Interaction of Escherichia coli cytotoxic necrotizing factor type 1 (CNF1) with cultured cells

L. Falzano, C. Fiorentini, P. Boquet, G. Donelli

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The cytotoxic necrotizing factor type 1 (CNF1) from E. coli causes necrosis in rabbit skin and multinucleation in cultured cells. Cells exposed to CNF1 were characterized by changes in actin organization, mainly consisting in the presence of well-developed stress fibers and membrane ruffles. The interaction of CNF1 with the cell cytoskeleton probably promotes the cell spreading and interferes with the cytokinesis, leading to the formation of giant multinucleated cells.

Original languageEnglish
JournalCytotechnology
Volume11
Issue number1 Supplement
DOIs
Publication statusPublished - Jan 1993

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Escherichia coli
Cultured Cells
Cells
Stress Fibers
Skin
Cytokinesis
Giant Cells
Cytoskeleton
Membranes
Fibers
Actins
Necrosis
Rabbits
cytotoxic necrotizing factor type 1

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Biotechnology

Cite this

Interaction of Escherichia coli cytotoxic necrotizing factor type 1 (CNF1) with cultured cells. / Falzano, L.; Fiorentini, C.; Boquet, P.; Donelli, G.

In: Cytotechnology, Vol. 11, No. 1 Supplement, 01.1993.

Research output: Contribution to journalArticle

Falzano, L. ; Fiorentini, C. ; Boquet, P. ; Donelli, G. / Interaction of Escherichia coli cytotoxic necrotizing factor type 1 (CNF1) with cultured cells. In: Cytotechnology. 1993 ; Vol. 11, No. 1 Supplement.
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