Interaction of human immunodeficiency virus-derived vectors with wild- type virus in transduced cells

Anatoly A. Bukovsky, Jin Ping Song, Luigi Naldini

Research output: Contribution to journalArticlepeer-review

Abstract

The interaction of human immunodeficiency virus (HIV)-derived vectors with wild-type virus was analyzed in transduced cells. Vector transcripts upregulated by infection had no measurable effect on HIV type 1 (HIV-1) expression but competed efficiently for encapsidation, inhibiting the infectivity and spread of HIV-1 in culture and leading to mobilization and recombination of the vector. These effects were abrogated with a self- inactivating vector.

Original languageEnglish
Pages (from-to)7087-7092
Number of pages6
JournalJournal of Virology
Volume73
Issue number8
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Immunology

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