Interaction of hypoglycemia with pyridostigmine or arginine on GH secretion in normal short children

J. Bellone, E. Bartolotta, G. Aimaretti, M. Bozzola, M. R. Valetto, V. Cherubini, S. Bellone, A. Barberis, E. Ghigo

Research output: Contribution to journalArticlepeer-review

Abstract

Hypoglycemia, acetylcholine (Ach) and amino acids have stimulatory effect on GH secretion in humans. To clarify interactions among these stimuli, we studied in 24 normal short children the effect of insulin-induced hypoglycemia (IH) alone and combined with pyridostigmine (PD), a cholinesterase inhibitor, or arginine (ARG). PD and ARG did not modify the GH-releasing effect of IH. Thus, IH, Ach and ARG have similar GH-releasing effect which is likely mediated by a common mechanism of action, i.e. inhibition of hypothalamic somatostatin (SS) release.

Original languageEnglish
Pages (from-to)259-264
Number of pages6
JournalNeuroendocrinology Letters
Volume17
Issue number4
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

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