Hypoglycemia, acetylcholine (Ach) and amino acids have stimulatory effect on GH secretion in humans. To clarify interactions among these stimuli, we studied in 24 normal short children the effect of insulin-induced hypoglycemia (IH) alone and combined with pyridostigmine (PD), a cholinesterase inhibitor, or arginine (ARG). PD and ARG did not modify the GH-releasing effect of IH. Thus, IH, Ach and ARG have similar GH-releasing effect which is likely mediated by a common mechanism of action, i.e. inhibition of hypothalamic somatostatin (SS) release.
|Number of pages||6|
|Publication status||Published - 1995|
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