Interaction of large granular lymphocytes with susceptible target does not induce second messenger And cytolytic granule exocytosis

F. Pollis, A. Rosato, V. Bronte, S. Mandruzzato, A. Zambon, R. Zambello, P. Pizzo, P. Zanovello

Research output: Contribution to journalArticle

Abstract

We studied the activation signals of LGL, from LDGL patients, following incubation with susceptible K562 target cells. The findings showed that LGL lysis is independent of [Ca2+]i rise and cytolytic granule exocytosis, and most likely involves alternative, as yet unidentified, mechanisms.

Original languageEnglish
JournalLeukemia
Volume6
Issue numberSUPPL. 3
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Hematology
  • Cancer Research

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