Interaction of large granular lymphocytes with susceptible target does not induce second messenger And cytolytic granule exocytosis

F. Pollis; A. Rosato; V. Bronte; S. Mandruzzato; A. Zambon; R. Zambello; P. Pizzo; P. Zanovello

Interaction of large granular lymphocytes with susceptible target does not induce second messenger And cytolytic granule exocytosis

F. Pollis, A. Rosato, V. Bronte, S. Mandruzzato, A. Zambon, R. Zambello, P. Pizzo, P. Zanovello

Istituto Oncologico Veneto

Research output: Contribution to journal › Article

Abstract

We studied the activation signals of LGL, from LDGL patients, following incubation with susceptible K562 target cells. The findings showed that LGL lysis is independent of [Ca²⁺]_i rise and cytolytic granule exocytosis, and most likely involves alternative, as yet unidentified, mechanisms.

Original language	English
Journal	Leukemia
Volume	6
Issue number	SUPPL. 3
Publication status	Published - 1992

ASJC Scopus subject areas

Hematology
Cancer Research

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Pollis, F., Rosato, A., Bronte, V., Mandruzzato, S., Zambon, A., Zambello, R., Pizzo, P., & Zanovello, P. (1992). Interaction of large granular lymphocytes with susceptible target does not induce second messenger And cytolytic granule exocytosis. Leukemia, 6(SUPPL. 3).

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abstract = "We studied the activation signals of LGL, from LDGL patients, following incubation with susceptible K562 target cells. The findings showed that LGL lysis is independent of [Ca2+]i rise and cytolytic granule exocytosis, and most likely involves alternative, as yet unidentified, mechanisms.",

author = "F. Pollis and A. Rosato and V. Bronte and S. Mandruzzato and A. Zambon and R. Zambello and P. Pizzo and P. Zanovello",

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AU - Pollis, F.

AU - Rosato, A.

AU - Bronte, V.

AU - Mandruzzato, S.

AU - Zambon, A.

AU - Zambello, R.

AU - Pizzo, P.

AU - Zanovello, P.

PY - 1992

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N2 - We studied the activation signals of LGL, from LDGL patients, following incubation with susceptible K562 target cells. The findings showed that LGL lysis is independent of [Ca2+]i rise and cytolytic granule exocytosis, and most likely involves alternative, as yet unidentified, mechanisms.

AB - We studied the activation signals of LGL, from LDGL patients, following incubation with susceptible K562 target cells. The findings showed that LGL lysis is independent of [Ca2+]i rise and cytolytic granule exocytosis, and most likely involves alternative, as yet unidentified, mechanisms.

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