Interaction of large granular lymphocytes with susceptible target does not induce second messenger And cytolytic granule exocytosis

F. Pollis; A. Rosato; V. Bronte; S. Mandruzzato; A. Zambon; R. Zambello; P. Pizzo; P. Zanovello

Interaction of large granular lymphocytes with susceptible target does not induce second messenger And cytolytic granule exocytosis

F. Pollis, A. Rosato, V. Bronte, S. Mandruzzato, A. Zambon, R. Zambello, P. Pizzo, P. Zanovello

Istituto Oncologico Veneto

Research output: Contribution to journal › Article › peer-review

Abstract

We studied the activation signals of LGL, from LDGL patients, following incubation with susceptible K562 target cells. The findings showed that LGL lysis is independent of [Ca²⁺]_i rise and cytolytic granule exocytosis, and most likely involves alternative, as yet unidentified, mechanisms.

Original language	English
Journal	Leukemia
Volume	6
Issue number	SUPPL. 3
Publication status	Published - 1992

ASJC Scopus subject areas

Hematology
Cancer Research

Cite this

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title = "Interaction of large granular lymphocytes with susceptible target does not induce second messenger And cytolytic granule exocytosis",

abstract = "We studied the activation signals of LGL, from LDGL patients, following incubation with susceptible K562 target cells. The findings showed that LGL lysis is independent of [Ca2+]i rise and cytolytic granule exocytosis, and most likely involves alternative, as yet unidentified, mechanisms.",

author = "F. Pollis and A. Rosato and V. Bronte and S. Mandruzzato and A. Zambon and R. Zambello and P. Pizzo and P. Zanovello",

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T1 - Interaction of large granular lymphocytes with susceptible target does not induce second messenger And cytolytic granule exocytosis

AU - Pollis, F.

AU - Rosato, A.

AU - Bronte, V.

AU - Mandruzzato, S.

AU - Zambon, A.

AU - Zambello, R.

AU - Pizzo, P.

AU - Zanovello, P.

PY - 1992

Y1 - 1992

N2 - We studied the activation signals of LGL, from LDGL patients, following incubation with susceptible K562 target cells. The findings showed that LGL lysis is independent of [Ca2+]i rise and cytolytic granule exocytosis, and most likely involves alternative, as yet unidentified, mechanisms.

AB - We studied the activation signals of LGL, from LDGL patients, following incubation with susceptible K562 target cells. The findings showed that LGL lysis is independent of [Ca2+]i rise and cytolytic granule exocytosis, and most likely involves alternative, as yet unidentified, mechanisms.

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M3 - Article

C2 - 1602835

AN - SCOPUS:0026637992

VL - 6

JO - Leukemia

JF - Leukemia

SN - 0887-6924

IS - SUPPL. 3

ER -

Interaction of large granular lymphocytes with susceptible target does not induce second messenger And cytolytic granule exocytosis

Abstract

ASJC Scopus subject areas

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