Interaction of metals in nickel-sensitive patients

B. Santucci, C. Cannistraci, A. Cristaudo, M. Picardo

Research output: Contribution to journalArticlepeer-review


Nickel (Ni) dermatitis is thought to involve the formation of complexes between Ni ions and suitable proteins. 4 groups of 30 subjects who gave positive patch test responses to NiSO4 2.9% aq. were each retested to 1 of 4 different solutions containing equimolar (0.1 M) amounts of NiSO4 plus MgSO4, NiSO4 plus CuSO4, NiSO4 plus ZnSO4, and NiSO4 plus Li2SO4, respectively. The results, evaluated at 2 days by visual scoring only, demonstrated that the 4 metals exerted a different influence on the nickel reactions, perhaps interfering with one or more factors affecting the formation of Ni++ complexes.

Original languageEnglish
Pages (from-to)251-253
Number of pages3
JournalContact Dermatitis
Issue number5
Publication statusPublished - 1993


  • Allergic contact dermatitis
  • Chemical basis
  • Immunological basis
  • Ni++ complexes
  • Nickel sensitivity

ASJC Scopus subject areas

  • Dermatology
  • Toxicology
  • Immunology


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