Interaction of metergoline with striatal dopamine system

P. F. Spano; G. Biggio; M. Casu; G. L. Gessa; S. R. Bareggi; S. Govoni; M. Trabucchi

doi:10.1016/0024-3205(78)90296-5

Interaction of metergoline with striatal dopamine system

P. F. Spano, G. Biggio, M. Casu, G. L. Gessa, S. R. Bareggi, S. Govoni, M. Trabucchi

Istituto di Neuroriabilitazione Motoria San Camillo

Research output: Contribution to journal › Article › peer-review

Abstract

The intragastric of intraperitoneal administration of metergoline (2.5-10 mg/kg) stimulates dopamine (DA) synthesis in the rat and mouse brain. In vitro, metergoline blocks DA-sensitive adenylate cyclase and displaces H³-haloperidol from specific binding sites in striatal homogenates.

Original language	English
Pages (from-to)	2383-2391
Number of pages	9
Journal	Life Sciences
Volume	23
Issue number	24
DOIs	https://doi.org/10.1016/0024-3205(78)90296-5
Publication status	Published - Dec 11 1978

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/0024-3205(78)90296-5

Fingerprint Dive into the research topics of 'Interaction of metergoline with striatal dopamine system'. Together they form a unique fingerprint.

Cite this

@article{4e1fff08107a45fd9694c250918a4e67,

title = "Interaction of metergoline with striatal dopamine system",

abstract = "The intragastric of intraperitoneal administration of metergoline (2.5-10 mg/kg) stimulates dopamine (DA) synthesis in the rat and mouse brain. In vitro, metergoline blocks DA-sensitive adenylate cyclase and displaces H3-haloperidol from specific binding sites in striatal homogenates.",

author = "Spano, {P. F.} and G. Biggio and M. Casu and Gessa, {G. L.} and Bareggi, {S. R.} and S. Govoni and M. Trabucchi",

year = "1978",

month = dec,

day = "11",

doi = "10.1016/0024-3205(78)90296-5",

language = "English",

volume = "23",

pages = "2383--2391",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "24",

}

TY - JOUR

T1 - Interaction of metergoline with striatal dopamine system

AU - Spano, P. F.

AU - Biggio, G.

AU - Casu, M.

AU - Gessa, G. L.

AU - Bareggi, S. R.

AU - Govoni, S.

AU - Trabucchi, M.

PY - 1978/12/11

Y1 - 1978/12/11

N2 - The intragastric of intraperitoneal administration of metergoline (2.5-10 mg/kg) stimulates dopamine (DA) synthesis in the rat and mouse brain. In vitro, metergoline blocks DA-sensitive adenylate cyclase and displaces H3-haloperidol from specific binding sites in striatal homogenates.

AB - The intragastric of intraperitoneal administration of metergoline (2.5-10 mg/kg) stimulates dopamine (DA) synthesis in the rat and mouse brain. In vitro, metergoline blocks DA-sensitive adenylate cyclase and displaces H3-haloperidol from specific binding sites in striatal homogenates.

UR - http://www.scopus.com/inward/record.url?scp=0018266308&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018266308&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(78)90296-5

DO - 10.1016/0024-3205(78)90296-5

M3 - Article

C2 - 745518

AN - SCOPUS:0018266308

VL - 23

SP - 2383

EP - 2391

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 24

ER -