Interaction of metergoline with striatal dopamine system

P. F. Spano, G. Biggio, M. Casu, G. L. Gessa, S. R. Bareggi, S. Govoni, M. Trabucchi

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The intragastric of intraperitoneal administration of metergoline (2.5-10 mg/kg) stimulates dopamine (DA) synthesis in the rat and mouse brain. In vitro, metergoline blocks DA-sensitive adenylate cyclase and displaces H3-haloperidol from specific binding sites in striatal homogenates.

Original languageEnglish
Pages (from-to)2383-2391
Number of pages9
JournalLife Sciences
Volume23
Issue number24
DOIs
Publication statusPublished - Dec 11 1978

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Metergoline
Corpus Striatum
Dopamine
Haloperidol
Adenylyl Cyclases
Rats
Brain
Binding Sites

ASJC Scopus subject areas

  • Pharmacology

Cite this

Spano, P. F., Biggio, G., Casu, M., Gessa, G. L., Bareggi, S. R., Govoni, S., & Trabucchi, M. (1978). Interaction of metergoline with striatal dopamine system. Life Sciences, 23(24), 2383-2391. https://doi.org/10.1016/0024-3205(78)90296-5

Interaction of metergoline with striatal dopamine system. / Spano, P. F.; Biggio, G.; Casu, M.; Gessa, G. L.; Bareggi, S. R.; Govoni, S.; Trabucchi, M.

In: Life Sciences, Vol. 23, No. 24, 11.12.1978, p. 2383-2391.

Research output: Contribution to journalArticle

Spano, PF, Biggio, G, Casu, M, Gessa, GL, Bareggi, SR, Govoni, S & Trabucchi, M 1978, 'Interaction of metergoline with striatal dopamine system', Life Sciences, vol. 23, no. 24, pp. 2383-2391. https://doi.org/10.1016/0024-3205(78)90296-5
Spano PF, Biggio G, Casu M, Gessa GL, Bareggi SR, Govoni S et al. Interaction of metergoline with striatal dopamine system. Life Sciences. 1978 Dec 11;23(24):2383-2391. https://doi.org/10.1016/0024-3205(78)90296-5
Spano, P. F. ; Biggio, G. ; Casu, M. ; Gessa, G. L. ; Bareggi, S. R. ; Govoni, S. ; Trabucchi, M. / Interaction of metergoline with striatal dopamine system. In: Life Sciences. 1978 ; Vol. 23, No. 24. pp. 2383-2391.
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