Interaction of metergoline with striatal dopamine system

P. F. Spano, G. Biggio, M. Casu, G. L. Gessa, S. R. Bareggi, S. Govoni, M. Trabucchi

Research output: Contribution to journalArticlepeer-review


The intragastric of intraperitoneal administration of metergoline (2.5-10 mg/kg) stimulates dopamine (DA) synthesis in the rat and mouse brain. In vitro, metergoline blocks DA-sensitive adenylate cyclase and displaces H3-haloperidol from specific binding sites in striatal homogenates.

Original languageEnglish
Pages (from-to)2383-2391
Number of pages9
JournalLife Sciences
Issue number24
Publication statusPublished - Dec 11 1978

ASJC Scopus subject areas

  • Pharmacology

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