Interaction of narcotic analgesics with dopamine receptors in rat brain

S. Govoni, K. Kumakura, P. F. Spano, G. C. Tonon, M. Trabucchi

Research output: Contribution to journalArticle

Abstract

Dopamine sensitive adenylate-cyclase was studied in rat striatal homogenate after incubation with several analgesic drugs. The compounds we studied are 3 to 100 times more effective than morphine in producing analgesia or catalepsy. These results suggest that the inhibitory effect of these compounds on DA-sensitive adenylate-cyclase roughly parallels their capacity to produce catalepsy and reflects their analgesic potency in rats.

Original languageEnglish
Pages (from-to)95-100
Number of pages6
JournalPharmacological Research Communications
Volume7
Issue number1
DOIs
Publication statusPublished - 1975

ASJC Scopus subject areas

  • Pharmacology

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