Abstract
Dopamine sensitive adenylate-cyclase was studied in rat striatal homogenate after incubation with several analgesic drugs. The compounds we studied are 3 to 100 times more effective than morphine in producing analgesia or catalepsy. These results suggest that the inhibitory effect of these compounds on DA-sensitive adenylate-cyclase roughly parallels their capacity to produce catalepsy and reflects their analgesic potency in rats.
| Original language | English |
|---|---|
| Pages (from-to) | 95-100 |
| Number of pages | 6 |
| Journal | Pharmacological Research Communications |
| Volume | 7 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1975 |
ASJC Scopus subject areas
- Pharmacology
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Cite this
Govoni, S., Kumakura, K., Spano, P. F., Tonon, G. C., & Trabucchi, M. (1975). Interaction of narcotic analgesics with dopamine receptors in rat brain. Pharmacological Research Communications, 7(1), 95-100. https://doi.org/10.1016/S0031-6989(75)80033-6