Interaction of narcotic analgesics with dopamine receptors in rat brain

S. Govoni, K. Kumakura, P. F. Spano, G. C. Tonon, M. Trabucchi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Dopamine sensitive adenylate-cyclase was studied in rat striatal homogenate after incubation with several analgesic drugs. The compounds we studied are 3 to 100 times more effective than morphine in producing analgesia or catalepsy. These results suggest that the inhibitory effect of these compounds on DA-sensitive adenylate-cyclase roughly parallels their capacity to produce catalepsy and reflects their analgesic potency in rats.

Original languageEnglish
Pages (from-to)95-100
Number of pages6
JournalPharmacological Research Communications
Volume7
Issue number1
DOIs
Publication statusPublished - 1975

Fingerprint

Catalepsy
Narcotics
Dopamine Receptors
Adenylyl Cyclases
Analgesics
Corpus Striatum
Brain
Analgesia
Morphine
Dopamine

ASJC Scopus subject areas

  • Pharmacology

Cite this

Interaction of narcotic analgesics with dopamine receptors in rat brain. / Govoni, S.; Kumakura, K.; Spano, P. F.; Tonon, G. C.; Trabucchi, M.

In: Pharmacological Research Communications, Vol. 7, No. 1, 1975, p. 95-100.

Research output: Contribution to journalArticle

Govoni, S. ; Kumakura, K. ; Spano, P. F. ; Tonon, G. C. ; Trabucchi, M. / Interaction of narcotic analgesics with dopamine receptors in rat brain. In: Pharmacological Research Communications. 1975 ; Vol. 7, No. 1. pp. 95-100.
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