Abstract
Dopamine sensitive adenylate-cyclase was studied in rat striatal homogenate after incubation with several analgesic drugs. The compounds we studied are 3 to 100 times more effective than morphine in producing analgesia or catalepsy. These results suggest that the inhibitory effect of these compounds on DA-sensitive adenylate-cyclase roughly parallels their capacity to produce catalepsy and reflects their analgesic potency in rats.
Original language | English |
---|---|
Pages (from-to) | 95-100 |
Number of pages | 6 |
Journal | Pharmacological Research Communications |
Volume | 7 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1975 |
ASJC Scopus subject areas
- Pharmacology