Interaction of narcotic analgesics with dopamine receptors in rat brain

S. Govoni; K. Kumakura; P. F. Spano; G. C. Tonon; M. Trabucchi

doi:10.1016/S0031-6989(75)80033-6

Interaction of narcotic analgesics with dopamine receptors in rat brain

S. Govoni, K. Kumakura, P. F. Spano, G. C. Tonon, M. Trabucchi

Istituto di Neuroriabilitazione Motoria San Camillo

Research output: Contribution to journal › Article › peer-review

Abstract

Dopamine sensitive adenylate-cyclase was studied in rat striatal homogenate after incubation with several analgesic drugs. The compounds we studied are 3 to 100 times more effective than morphine in producing analgesia or catalepsy. These results suggest that the inhibitory effect of these compounds on DA-sensitive adenylate-cyclase roughly parallels their capacity to produce catalepsy and reflects their analgesic potency in rats.

Original language	English
Pages (from-to)	95-100
Number of pages	6
Journal	Pharmacological Research Communications
Volume	7
Issue number	1
DOIs	https://doi.org/10.1016/S0031-6989(75)80033-6
Publication status	Published - 1975

ASJC Scopus subject areas

Pharmacology

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10.1016/S0031-6989(75)80033-6

Cite this

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title = "Interaction of narcotic analgesics with dopamine receptors in rat brain",

abstract = "Dopamine sensitive adenylate-cyclase was studied in rat striatal homogenate after incubation with several analgesic drugs. The compounds we studied are 3 to 100 times more effective than morphine in producing analgesia or catalepsy. These results suggest that the inhibitory effect of these compounds on DA-sensitive adenylate-cyclase roughly parallels their capacity to produce catalepsy and reflects their analgesic potency in rats.",

author = "S. Govoni and K. Kumakura and Spano, {P. F.} and Tonon, {G. C.} and M. Trabucchi",

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AU - Govoni, S.

AU - Kumakura, K.

AU - Spano, P. F.

AU - Tonon, G. C.

AU - Trabucchi, M.

PY - 1975

Y1 - 1975

N2 - Dopamine sensitive adenylate-cyclase was studied in rat striatal homogenate after incubation with several analgesic drugs. The compounds we studied are 3 to 100 times more effective than morphine in producing analgesia or catalepsy. These results suggest that the inhibitory effect of these compounds on DA-sensitive adenylate-cyclase roughly parallels their capacity to produce catalepsy and reflects their analgesic potency in rats.

AB - Dopamine sensitive adenylate-cyclase was studied in rat striatal homogenate after incubation with several analgesic drugs. The compounds we studied are 3 to 100 times more effective than morphine in producing analgesia or catalepsy. These results suggest that the inhibitory effect of these compounds on DA-sensitive adenylate-cyclase roughly parallels their capacity to produce catalepsy and reflects their analgesic potency in rats.

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Interaction of narcotic analgesics with dopamine receptors in rat brain

Abstract

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