Abstract
Dopamine sensitive adenylate-cyclase was studied in rat striatal homogenate after incubation with several analgesic drugs. The compounds we studied are 3 to 100 times more effective than morphine in producing analgesia or catalepsy. These results suggest that the inhibitory effect of these compounds on DA-sensitive adenylate-cyclase roughly parallels their capacity to produce catalepsy and reflects their analgesic potency in rats.
| Original language | English |
|---|---|
| Pages (from-to) | 95-100 |
| Number of pages | 6 |
| Journal | Pharmacological Research Communications |
| Volume | 7 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1975 |
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ASJC Scopus subject areas
- Pharmacology
Cite this
Interaction of narcotic analgesics with dopamine receptors in rat brain. / Govoni, S.; Kumakura, K.; Spano, P. F.; Tonon, G. C.; Trabucchi, M.
In: Pharmacological Research Communications, Vol. 7, No. 1, 1975, p. 95-100.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interaction of narcotic analgesics with dopamine receptors in rat brain
AU - Govoni, S.
AU - Kumakura, K.
AU - Spano, P. F.
AU - Tonon, G. C.
AU - Trabucchi, M.
PY - 1975
Y1 - 1975
N2 - Dopamine sensitive adenylate-cyclase was studied in rat striatal homogenate after incubation with several analgesic drugs. The compounds we studied are 3 to 100 times more effective than morphine in producing analgesia or catalepsy. These results suggest that the inhibitory effect of these compounds on DA-sensitive adenylate-cyclase roughly parallels their capacity to produce catalepsy and reflects their analgesic potency in rats.
AB - Dopamine sensitive adenylate-cyclase was studied in rat striatal homogenate after incubation with several analgesic drugs. The compounds we studied are 3 to 100 times more effective than morphine in producing analgesia or catalepsy. These results suggest that the inhibitory effect of these compounds on DA-sensitive adenylate-cyclase roughly parallels their capacity to produce catalepsy and reflects their analgesic potency in rats.
UR - http://www.scopus.com/inward/record.url?scp=0016409423&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016409423&partnerID=8YFLogxK
U2 - 10.1016/S0031-6989(75)80033-6
DO - 10.1016/S0031-6989(75)80033-6
M3 - Article
C2 - 239406
AN - SCOPUS:0016409423
VL - 7
SP - 95
EP - 100
JO - Pharmacological Research
JF - Pharmacological Research
SN - 1043-6618
IS - 1
ER -