Interaction of natural killer cells with extracellular matrix induces early intracellular signalling events and enhances cytotoxic functions

G. Palmieri, A. Gismondi, R. Galandrini, M. Milella, A. Serra, R. De Maria, A. Santoni

Research output: Contribution to journalArticle

Abstract

NK cells are endowed with a wide array of adhesion molecules which mediate their interaction with endothelium and extracellular matrix components. We have shown that cross-linking of β1 integrins and CD44 on human NK cells induces a signal transduction pathway involving both tyrosine kinase activation and the modulation of intracellular calcium levels. Our studies have also demonstrated the ability of β1 integrins and CD44 to upregulate both the spontaneous and the CD16-triggered cytotoxic activity of human NK cells. Although the molecular mechanisms responsible for this costimulatory activity have not been defined yet, our studies indicate that the simultaneous cross-linking of β1 integrins and CD44 results in a synergistic effect on CD16-mediated enhancement of intracellular free calcium concentration, and suggest that this may be relevant for the cooperation observed.

Original languageEnglish
Pages (from-to)147-153
Number of pages7
JournalNatural Immunity
Volume15
Issue number2-3
Publication statusPublished - Feb 1997

Keywords

  • Adhesion receptors
  • Cytotoxic function
  • Extracellular matrix
  • NK cells
  • Signal transduction

ASJC Scopus subject areas

  • Immunology

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