Abstract
NK cells are endowed with a wide array of adhesion molecules which mediate their interaction with endothelium and extracellular matrix components. We have shown that cross-linking of β1 integrins and CD44 on human NK cells induces a signal transduction pathway involving both tyrosine kinase activation and the modulation of intracellular calcium levels. Our studies have also demonstrated the ability of β1 integrins and CD44 to upregulate both the spontaneous and the CD16-triggered cytotoxic activity of human NK cells. Although the molecular mechanisms responsible for this costimulatory activity have not been defined yet, our studies indicate that the simultaneous cross-linking of β1 integrins and CD44 results in a synergistic effect on CD16-mediated enhancement of intracellular free calcium concentration, and suggest that this may be relevant for the cooperation observed.
| Original language | English |
|---|---|
| Pages (from-to) | 147-153 |
| Number of pages | 7 |
| Journal | Natural Immunity |
| Volume | 15 |
| Issue number | 2-3 |
| Publication status | Published - Feb 1997 |
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Keywords
- Adhesion receptors
- Cytotoxic function
- Extracellular matrix
- NK cells
- Signal transduction
ASJC Scopus subject areas
- Immunology
Cite this
Interaction of natural killer cells with extracellular matrix induces early intracellular signalling events and enhances cytotoxic functions. / Palmieri, G.; Gismondi, A.; Galandrini, R.; Milella, M.; Serra, A.; De Maria, R.; Santoni, A.
In: Natural Immunity, Vol. 15, No. 2-3, 02.1997, p. 147-153.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interaction of natural killer cells with extracellular matrix induces early intracellular signalling events and enhances cytotoxic functions
AU - Palmieri, G.
AU - Gismondi, A.
AU - Galandrini, R.
AU - Milella, M.
AU - Serra, A.
AU - De Maria, R.
AU - Santoni, A.
PY - 1997/2
Y1 - 1997/2
N2 - NK cells are endowed with a wide array of adhesion molecules which mediate their interaction with endothelium and extracellular matrix components. We have shown that cross-linking of β1 integrins and CD44 on human NK cells induces a signal transduction pathway involving both tyrosine kinase activation and the modulation of intracellular calcium levels. Our studies have also demonstrated the ability of β1 integrins and CD44 to upregulate both the spontaneous and the CD16-triggered cytotoxic activity of human NK cells. Although the molecular mechanisms responsible for this costimulatory activity have not been defined yet, our studies indicate that the simultaneous cross-linking of β1 integrins and CD44 results in a synergistic effect on CD16-mediated enhancement of intracellular free calcium concentration, and suggest that this may be relevant for the cooperation observed.
AB - NK cells are endowed with a wide array of adhesion molecules which mediate their interaction with endothelium and extracellular matrix components. We have shown that cross-linking of β1 integrins and CD44 on human NK cells induces a signal transduction pathway involving both tyrosine kinase activation and the modulation of intracellular calcium levels. Our studies have also demonstrated the ability of β1 integrins and CD44 to upregulate both the spontaneous and the CD16-triggered cytotoxic activity of human NK cells. Although the molecular mechanisms responsible for this costimulatory activity have not been defined yet, our studies indicate that the simultaneous cross-linking of β1 integrins and CD44 results in a synergistic effect on CD16-mediated enhancement of intracellular free calcium concentration, and suggest that this may be relevant for the cooperation observed.
KW - Adhesion receptors
KW - Cytotoxic function
KW - Extracellular matrix
KW - NK cells
KW - Signal transduction
UR - http://www.scopus.com/inward/record.url?scp=8044244197&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=8044244197&partnerID=8YFLogxK
M3 - Article
VL - 15
SP - 147
EP - 153
JO - Natural Immunity
JF - Natural Immunity
SN - 1018-8916
IS - 2-3
ER -