Interaction of Single Cells with 2D Organic Monolayers: A Scanning Electrochemical Microscopy Study

Luca Bartolini, Marco Malferrari, Francesca Lugli, Francesco Zerbetto, Francesco Paolucci, Pier Giuseppe Pelicci, Cristiano Albonetti, Stefania Rapino

Research output: Contribution to journalArticlepeer-review

Abstract

Cell shape is a valuable indicator of cell health status and interactions with the extracellular materials. With the aim to investigate how individual cells respond to chemical microenvironments, we employed 2D monomolecular layers of small organic molecules, characterized by very low roughness. MCF10A cells were grown on these surfaces and characterized by using scanning electrochemical microscopy. The single cell morphologies were analyzed to define a “figure of merit” for the different cell–surface interactions. Such “figure of merit” quantifies the interaction with the microenvironment. This method is applicable to any cell state (metastatic, physiological or pathological) and any surface.

Original languageEnglish
Pages (from-to)2975-2981
Number of pages7
JournalChemElectroChem
Volume5
Issue number20
DOIs
Publication statusPublished - Oct 12 2018

Keywords

  • cell contact angle
  • cell morphology
  • organic monolayers
  • SECM
  • single cell

ASJC Scopus subject areas

  • Catalysis
  • Electrochemistry

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