Interaction of ultraviolet light with the cornea: Clinical implications for corneal crosslinking

Marco Lombardo, Giuseppe Pucci, Riccardo Barberi, Giuseppe Lombardo

Research output: Contribution to journalArticlepeer-review


Understanding ultraviolet (UV) interaction with the human corneal tissue is of interest among corneal specialists given the widespread application of corneal crosslinking. This article reviews the current knowledge of light interaction with the cornea in the UV wavelength range. It also uses a novel experimental study to illustrate the role of 2 important corneal properties that have not yet been clarified: the epithelial contribution to overall UVA corneal absorbance and the regional anisotropy of UVA light transmittance. Finally, it presents the most recent insights into how different methods of UVA light irradiation and corneal soaking with riboflavin influence the outcome of corneal crosslinking. Financial Disclosure No author has a financial or proprietary interest in any material or method mentioned.

Original languageEnglish
Pages (from-to)446-449
Number of pages4
JournalJournal of Cataract and Refractive Surgery
Issue number2
Publication statusPublished - Feb 1 2015

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Surgery
  • Medicine(all)


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