Interaction of von willebrand factor with platelets and the vessel wall

Zaverio M. Ruggeri, G. L. Mendolicchio

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The initiation of thrombus formation at sites of vascular injury to secure haemostasis after tissue trauma requires the interaction of surface- exposed von Willebrand factor (VWF) with its primary platelet receptor, the glycoprotein (GP) Ib-IX-V complex. As an insoluble component of the extracellular matrix (ECM) of endothelial cells, VWF can directly initiate platelet adhesion. Circulating plasma VWF en-hances matrix VWF activity by binding to structures that become exposed to flowing blood, notably collagen type I and III in deeper layers of the vessel along with microfibrillar collagen type VI in the sub - endothelium. Moreover, plasma VWF is required to support platelet-to-platelet adhesion - i. e. aggregation - which promotes thrombus growth and consolidation. For these reasons, understanding how plasma VWF interaction with platelet receptors is regulated, particularly any distinctive features of GPIb binding to soluble as opposed to immobilized VWF, is of paramount importance in vascular biology. This brief review will highlight knowledge acquired and key problems that remain to be solved to elucidate fully the role of VWF in normal haemostasis and pathological thrombosis.

Original languageEnglish
Pages (from-to)211-224
Number of pages14
JournalHamostaseologie
Volume35
Issue number3
Publication statusPublished - 2015

Fingerprint

von Willebrand Factor
Blood Platelets
Thrombosis
Hemostasis
Collagen Type VI
Platelet Glycoprotein GPIb-IX Complex
Platelet Membrane Glycoproteins
Collagen Type III
Vascular System Injuries
Collagen Type I
Endothelium
Extracellular Matrix
Blood Vessels
Endothelial Cells
Wounds and Injuries
Growth

Keywords

  • Von willebrand factor

ASJC Scopus subject areas

  • Hematology

Cite this

Ruggeri, Z. M., & Mendolicchio, G. L. (2015). Interaction of von willebrand factor with platelets and the vessel wall. Hamostaseologie, 35(3), 211-224.

Interaction of von willebrand factor with platelets and the vessel wall. / Ruggeri, Zaverio M.; Mendolicchio, G. L.

In: Hamostaseologie, Vol. 35, No. 3, 2015, p. 211-224.

Research output: Contribution to journalArticle

Ruggeri, ZM & Mendolicchio, GL 2015, 'Interaction of von willebrand factor with platelets and the vessel wall', Hamostaseologie, vol. 35, no. 3, pp. 211-224.
Ruggeri, Zaverio M. ; Mendolicchio, G. L. / Interaction of von willebrand factor with platelets and the vessel wall. In: Hamostaseologie. 2015 ; Vol. 35, No. 3. pp. 211-224.
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