Abstract
Small doses of the beta-adrenergic blocking agent propranolol added to a regimen of diuretic treatment with chlorthalidone in outpatients with essential hypertension depressed the rise in plasma renin activity induced by chlorthalidone significantly although not entirely. Simultaneously, a reduction in blood pressure occurred beyond that already achieved by the diuretic agent. Increasing the dose of propranolol, from 40 to 160 mg/day, caused an additional antihypertensive response with no further renin depression. It is concluded that the antihypertensive effect of large doses of propranolol is due mainly to a renin-independent mechanism, but the reduction in pressure that follows addition of a small dose of the beta blocker may be due to a renin-dependent mechanism brought into action by the rise in plasma renin that is induced by concurrent diuretic therapy.
| Original language | English |
|---|---|
| Pages (from-to) | 43-52 |
| Number of pages | 10 |
| Journal | Cardiovascular Medicine |
| Volume | 4 |
| Issue number | 1 |
| Publication status | Published - 1979 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
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Interactions between diuretics and propranolol in treatment of arterial hypertension. / Morganti, A. A.; Terzoli, L.; Sala, C.
In: Cardiovascular Medicine, Vol. 4, No. 1, 1979, p. 43-52.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interactions between diuretics and propranolol in treatment of arterial hypertension
AU - Morganti, A. A.
AU - Terzoli, L.
AU - Sala, C.
PY - 1979
Y1 - 1979
N2 - Small doses of the beta-adrenergic blocking agent propranolol added to a regimen of diuretic treatment with chlorthalidone in outpatients with essential hypertension depressed the rise in plasma renin activity induced by chlorthalidone significantly although not entirely. Simultaneously, a reduction in blood pressure occurred beyond that already achieved by the diuretic agent. Increasing the dose of propranolol, from 40 to 160 mg/day, caused an additional antihypertensive response with no further renin depression. It is concluded that the antihypertensive effect of large doses of propranolol is due mainly to a renin-independent mechanism, but the reduction in pressure that follows addition of a small dose of the beta blocker may be due to a renin-dependent mechanism brought into action by the rise in plasma renin that is induced by concurrent diuretic therapy.
AB - Small doses of the beta-adrenergic blocking agent propranolol added to a regimen of diuretic treatment with chlorthalidone in outpatients with essential hypertension depressed the rise in plasma renin activity induced by chlorthalidone significantly although not entirely. Simultaneously, a reduction in blood pressure occurred beyond that already achieved by the diuretic agent. Increasing the dose of propranolol, from 40 to 160 mg/day, caused an additional antihypertensive response with no further renin depression. It is concluded that the antihypertensive effect of large doses of propranolol is due mainly to a renin-independent mechanism, but the reduction in pressure that follows addition of a small dose of the beta blocker may be due to a renin-dependent mechanism brought into action by the rise in plasma renin that is induced by concurrent diuretic therapy.
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UR - http://www.scopus.com/inward/citedby.url?scp=0018748116&partnerID=8YFLogxK
M3 - Article
VL - 4
SP - 43
EP - 52
JO - Cardiovascular Medicine
JF - Cardiovascular Medicine
SN - 0199-6614
IS - 1
ER -