Interactions between diuretics and propranolol in treatment of arterial hypertension

A. A. Morganti, L. Terzoli, C. Sala

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Small doses of the beta-adrenergic blocking agent propranolol added to a regimen of diuretic treatment with chlorthalidone in outpatients with essential hypertension depressed the rise in plasma renin activity induced by chlorthalidone significantly although not entirely. Simultaneously, a reduction in blood pressure occurred beyond that already achieved by the diuretic agent. Increasing the dose of propranolol, from 40 to 160 mg/day, caused an additional antihypertensive response with no further renin depression. It is concluded that the antihypertensive effect of large doses of propranolol is due mainly to a renin-independent mechanism, but the reduction in pressure that follows addition of a small dose of the beta blocker may be due to a renin-dependent mechanism brought into action by the rise in plasma renin that is induced by concurrent diuretic therapy.

Original languageEnglish
Pages (from-to)43-52
Number of pages10
JournalCardiovascular Medicine
Volume4
Issue number1
Publication statusPublished - 1979

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Diuretics
Renin
Propranolol
Hypertension
Chlorthalidone
Antihypertensive Agents
Therapeutics
Adrenergic beta-Antagonists
Outpatients
Blood Pressure
Pressure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Interactions between diuretics and propranolol in treatment of arterial hypertension. / Morganti, A. A.; Terzoli, L.; Sala, C.

In: Cardiovascular Medicine, Vol. 4, No. 1, 1979, p. 43-52.

Research output: Contribution to journalArticle

Morganti, AA, Terzoli, L & Sala, C 1979, 'Interactions between diuretics and propranolol in treatment of arterial hypertension', Cardiovascular Medicine, vol. 4, no. 1, pp. 43-52.
Morganti, A. A. ; Terzoli, L. ; Sala, C. / Interactions between diuretics and propranolol in treatment of arterial hypertension. In: Cardiovascular Medicine. 1979 ; Vol. 4, No. 1. pp. 43-52.
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