Interactions between growth factor receptors and adhesion molecules: Breaking the rules

Research output: Contribution to journalArticle

Abstract

Adhesion molecules, although catalytically inactive, are able to translate environmental cues into complex intracellular signals. They can do this by associating with tyrosine kinase receptors for growth factors, which can prime, integrate or feedback adhesion-based signals. Recent results show that reciprocal crosstalk between the two systems is only one facet of such a collaboration, and that unconventional and alternative hierarchies can be established in which, on the one hand, cell adhesion can trigger ligand-independent activation of growth factor receptors, and, on the other, growth factors can induce adhesion molecules to propagate adhesion-independent signals.

Original languageEnglish
Pages (from-to)565-571
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume15
Issue number5
DOIs
Publication statusPublished - Oct 2003

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Growth Factor Receptors
Intercellular Signaling Peptides and Proteins
Receptor Protein-Tyrosine Kinases
Cell Adhesion
Cues
Ligands

ASJC Scopus subject areas

  • Cell Biology

Cite this

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abstract = "Adhesion molecules, although catalytically inactive, are able to translate environmental cues into complex intracellular signals. They can do this by associating with tyrosine kinase receptors for growth factors, which can prime, integrate or feedback adhesion-based signals. Recent results show that reciprocal crosstalk between the two systems is only one facet of such a collaboration, and that unconventional and alternative hierarchies can be established in which, on the one hand, cell adhesion can trigger ligand-independent activation of growth factor receptors, and, on the other, growth factors can induce adhesion molecules to propagate adhesion-independent signals.",
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