Interactions between serotonergic and enkephalinergic neurons in rat striatum and hypothalamus

Laura Dellavedova, Marco Parenti, Felice Tirone, Antonio Groppetti

Research output: Contribution to journalArticlepeer-review

Abstract

We report evidence for an interaction between serotonergic and enkephalinergic neurons in rat striatum and hypothalamus. The administration of drugs such as p-chlorophenylalanine (PCPA), 5,6-dihydroxytryptamine (5,6-DHT) and fenfluramine that lower the striatal and hypothalamic serotonin (5-HT) content caused an increase in Met-enkephalin-like immunoreactive material (ME-IR) in these brain areas. Moreover, chronic treatment with PCPA induced an increase in the number of striatal [3H][D-Ala2, Met5]enkephalinamide binding sites. These observations suggest that serotonergic neurons modulate the functional activity of enkephalinergic neurons in the rat striatum and hypothalamus. The significance of this interaction is discussed.

Original languageEnglish
Pages (from-to)29-34
Number of pages6
JournalEuropean Journal of Pharmacology
Volume85
Issue number1
DOIs
Publication statusPublished - Nov 5 1982

Keywords

  • Hypothalamus
  • Serotonin
  • Striatum
  • [Met]enkephalin

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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