TY - JOUR
T1 - Interactions between serotonergic and enkephalinergic neurons in rat striatum and hypothalamus
AU - Dellavedova, Laura
AU - Parenti, Marco
AU - Tirone, Felice
AU - Groppetti, Antonio
PY - 1982/11/5
Y1 - 1982/11/5
N2 - We report evidence for an interaction between serotonergic and enkephalinergic neurons in rat striatum and hypothalamus. The administration of drugs such as p-chlorophenylalanine (PCPA), 5,6-dihydroxytryptamine (5,6-DHT) and fenfluramine that lower the striatal and hypothalamic serotonin (5-HT) content caused an increase in Met-enkephalin-like immunoreactive material (ME-IR) in these brain areas. Moreover, chronic treatment with PCPA induced an increase in the number of striatal [3H][D-Ala2, Met5]enkephalinamide binding sites. These observations suggest that serotonergic neurons modulate the functional activity of enkephalinergic neurons in the rat striatum and hypothalamus. The significance of this interaction is discussed.
AB - We report evidence for an interaction between serotonergic and enkephalinergic neurons in rat striatum and hypothalamus. The administration of drugs such as p-chlorophenylalanine (PCPA), 5,6-dihydroxytryptamine (5,6-DHT) and fenfluramine that lower the striatal and hypothalamic serotonin (5-HT) content caused an increase in Met-enkephalin-like immunoreactive material (ME-IR) in these brain areas. Moreover, chronic treatment with PCPA induced an increase in the number of striatal [3H][D-Ala2, Met5]enkephalinamide binding sites. These observations suggest that serotonergic neurons modulate the functional activity of enkephalinergic neurons in the rat striatum and hypothalamus. The significance of this interaction is discussed.
KW - Hypothalamus
KW - Serotonin
KW - Striatum
KW - [Met]enkephalin
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U2 - 10.1016/0014-2999(82)90421-6
DO - 10.1016/0014-2999(82)90421-6
M3 - Article
C2 - 7151862
AN - SCOPUS:0020458094
VL - 85
SP - 29
EP - 34
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1
ER -