Interactions between serotonergic and enkephalinergic neurons in rat striatum and hypothalamus

Laura Dellavedova; Marco Parenti; Felice Tirone; Antonio Groppetti

doi:10.1016/0014-2999(82)90421-6

Interactions between serotonergic and enkephalinergic neurons in rat striatum and hypothalamus

Laura Dellavedova, Marco Parenti, Felice Tirone, Antonio Groppetti

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

We report evidence for an interaction between serotonergic and enkephalinergic neurons in rat striatum and hypothalamus. The administration of drugs such as p-chlorophenylalanine (PCPA), 5,6-dihydroxytryptamine (5,6-DHT) and fenfluramine that lower the striatal and hypothalamic serotonin (5-HT) content caused an increase in Met-enkephalin-like immunoreactive material (ME-IR) in these brain areas. Moreover, chronic treatment with PCPA induced an increase in the number of striatal [³H][D-Ala², Met⁵]enkephalinamide binding sites. These observations suggest that serotonergic neurons modulate the functional activity of enkephalinergic neurons in the rat striatum and hypothalamus. The significance of this interaction is discussed.

Original language	English
Pages (from-to)	29-34
Number of pages	6
Journal	European Journal of Pharmacology
Volume	85
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(82)90421-6
Publication status	Published - Nov 5 1982

Keywords

Hypothalamus
Serotonin
Striatum
[Met]enkephalin

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Pharmacology

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10.1016/0014-2999(82)90421-6

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abstract = "We report evidence for an interaction between serotonergic and enkephalinergic neurons in rat striatum and hypothalamus. The administration of drugs such as p-chlorophenylalanine (PCPA), 5,6-dihydroxytryptamine (5,6-DHT) and fenfluramine that lower the striatal and hypothalamic serotonin (5-HT) content caused an increase in Met-enkephalin-like immunoreactive material (ME-IR) in these brain areas. Moreover, chronic treatment with PCPA induced an increase in the number of striatal [3H][D-Ala2, Met5]enkephalinamide binding sites. These observations suggest that serotonergic neurons modulate the functional activity of enkephalinergic neurons in the rat striatum and hypothalamus. The significance of this interaction is discussed.",

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AU - Dellavedova, Laura

AU - Parenti, Marco

AU - Tirone, Felice

AU - Groppetti, Antonio

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N2 - We report evidence for an interaction between serotonergic and enkephalinergic neurons in rat striatum and hypothalamus. The administration of drugs such as p-chlorophenylalanine (PCPA), 5,6-dihydroxytryptamine (5,6-DHT) and fenfluramine that lower the striatal and hypothalamic serotonin (5-HT) content caused an increase in Met-enkephalin-like immunoreactive material (ME-IR) in these brain areas. Moreover, chronic treatment with PCPA induced an increase in the number of striatal [3H][D-Ala2, Met5]enkephalinamide binding sites. These observations suggest that serotonergic neurons modulate the functional activity of enkephalinergic neurons in the rat striatum and hypothalamus. The significance of this interaction is discussed.

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