Interactions between the sympathetic nervous system and atrial natriuretic factor in the control of renal functions

Simonetta Genovesi, Giuseppe Protasoni, Cinzia Assi, Raffaello Goliri, Andrea Stella, Alberto Zanchetti

Research output: Contribution to journalArticle

Abstract

We studied neural influences on the renal actions of atrial peptides in anaesthetized cats by comparing the response to atrial natriuretic factor (ANF) infusion in the innervated kidney and in the contralateral surgically denervated kidney. During ANF infusion arterial pressure decreased, the heart rate did not change and blood flow to both kidneys increased slightly. Vascular conductances became slightly but significantly higher in the denervated kidneys than in the controls. In both kidneys, the glomerular filtration rate increased transiently and significantly. Inhibition of renin release was more prompt and larger in the innervated than in the denervated kidneys. ANF infusion caused a significant increase in sodium and water excretion from both the innervated and denervated kidneys. However, the diuretic and natriuretic effect in the innervated kidneys, although proportionally greater than that in the denervated kidneys, was of shorter duration and subsided after 20min of ANF infusion. Efferent renal nerve activity did not change during the initial 10 min of ANF infusion but thereafter increased progressively and significantly. We conclude that the effects of atrial peptides on renin release and excretory functions are influenced by renal nerve activity.

Original languageEnglish
Pages (from-to)703-710
Number of pages8
JournalJournal of Hypertension
Volume8
Issue number8
Publication statusPublished - 1990

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Keywords

  • Atrial natriuretic factor
  • Cats
  • Renal functions
  • Renal nerves
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Endocrinology

Cite this

Genovesi, S., Protasoni, G., Assi, C., Goliri, R., Stella, A., & Zanchetti, A. (1990). Interactions between the sympathetic nervous system and atrial natriuretic factor in the control of renal functions. Journal of Hypertension, 8(8), 703-710.