Interactions between tissue fibroblasts in lymph nodes and Hodgkin/Reed-Sternberg cells

Donatella Aldinucci, Debora Lorenzon, Karin Olivo, Barbara Rapanà, Valter Gattei

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Classic Hodgkin's Disease (cHD) is a lymphoid neoplasia characterized by a few malignant Hodgkin and Reed-Sternberg (H-RS) cells embedded in an abundant background of non-tumor cells. In this context, fibrosis is a common morphologic feature of HD lesions, being found more frequently in cHD subtypes. The clinical and histopathologic features of cHD are thought to be largely due to the effects of a wide variety of cytokines and chemokines primarily produced by H-RS cells, as well as by the surrounding reactive component. In the present review, first we propose three mechanisms putatively explaining fibroblast activation and fibrosis in HD: (1) unbalanced production of the pro-fibrogenic Th2 over Th1 cytokines; (2) production of TGF-β, b-FGF and IL-13 by H-RS cells; (3) activation of fibroblasts by CD40L-expressing cells of the HD microenvironment. Second, we suggest some molecular pathways involving cytokines produced by HD-derived fibroblasts (SCF, IL-7, IL-6) supposedly responsible for H-RS proliferation and rescue from apoptosis. Finally, we describe the role of specific molecules produced by H-RS cells in the regulation of HD-derived fibroblast production of chemokines, in turn involved in T-lymphocytes and recruitment of eosinophils.

Original languageEnglish
Pages (from-to)1731-1739
Number of pages9
JournalLeukemia and Lymphoma
Volume45
Issue number9
DOIs
Publication statusPublished - Sep 2004

Fingerprint

Reed-Sternberg Cells
Hodgkin Disease
Fibroblasts
Lymph Nodes
Cytokines
Chemokines
Fibrosis
Cellular Microenvironment
Interleukin-7
CD40 Ligand
Interleukin-13
Eosinophils
Interleukin-6
Apoptosis
T-Lymphocytes

Keywords

  • C-kit receptor
  • Chemokines
  • Fibroblasts from Hodgkin's disease-involved lymph nodes
  • H-RS cell growth

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Interactions between tissue fibroblasts in lymph nodes and Hodgkin/Reed-Sternberg cells. / Aldinucci, Donatella; Lorenzon, Debora; Olivo, Karin; Rapanà, Barbara; Gattei, Valter.

In: Leukemia and Lymphoma, Vol. 45, No. 9, 09.2004, p. 1731-1739.

Research output: Contribution to journalArticle

Aldinucci, Donatella ; Lorenzon, Debora ; Olivo, Karin ; Rapanà, Barbara ; Gattei, Valter. / Interactions between tissue fibroblasts in lymph nodes and Hodgkin/Reed-Sternberg cells. In: Leukemia and Lymphoma. 2004 ; Vol. 45, No. 9. pp. 1731-1739.
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