Interactions between tumor cells and vascular endothelium.-II) Light and electron microscopic studies.

P. Almasio, C. Marchetti, F. Piovella, M. M. Ricetti, E. Ascari

Research output: Contribution to journalArticle


Electron microscope technique was used to investigate the passage across the endothelial monolayer by murine tumor lines. After the initial adhesion, cancer cells induce a retraction of endothelium and migrate under vascular intima. Subsequently they spread on basement membrane showing a flattened shape, meanwhile endothelial cells reconstitute the monolayer. The four tumor lines show a similar behaviour being able to induce endothelial retraction and exposure of extracellular matrix and cross through the monolayer. The technique appears useful to study in details this multi-step process.

Original languageEnglish
Pages (from-to)1544-1550
Number of pages7
JournalBollettino della Societa Italiana di Biologia Sperimentale
Issue number10
Publication statusPublished - Oct 30 1983


ASJC Scopus subject areas

  • Medicine(all)

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