Abstract
Recent studies of mucosal immunity suggest a key role for dendritic cells in the regulation of gut immune responses, in both physiological and pathological conditions. Dendritic cells are widely distributed in the lamina propria of the gut and are involved in direct bacterial uptake across mucosal surfaces, which questions the role of dendritic cells in innate mucosal responses. Approximately 400 commensal microbial species are present in the gut lumen. So how do dendritic cells distinguish pathogens from luminal microflora? Are the cytokines and chemokines induced in dendritic cells tailored to the class of microbes being recognized? Several very important questions still need to be addressed.
| Original language | English |
|---|---|
| Pages (from-to) | 72-76 |
| Number of pages | 5 |
| Journal | Current Opinion in Microbiology |
| Volume | 6 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Feb 2003 |
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ASJC Scopus subject areas
- Infectious Diseases
- Microbiology
Cite this
Interactions of bacterial pathogens with dendritic cells during invasion of mucosal surfaces. / Granucci, Francesca; Ricciardi-Castagnoli, Paola.
In: Current Opinion in Microbiology, Vol. 6, No. 1, 02.2003, p. 72-76.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interactions of bacterial pathogens with dendritic cells during invasion of mucosal surfaces
AU - Granucci, Francesca
AU - Ricciardi-Castagnoli, Paola
PY - 2003/2
Y1 - 2003/2
N2 - Recent studies of mucosal immunity suggest a key role for dendritic cells in the regulation of gut immune responses, in both physiological and pathological conditions. Dendritic cells are widely distributed in the lamina propria of the gut and are involved in direct bacterial uptake across mucosal surfaces, which questions the role of dendritic cells in innate mucosal responses. Approximately 400 commensal microbial species are present in the gut lumen. So how do dendritic cells distinguish pathogens from luminal microflora? Are the cytokines and chemokines induced in dendritic cells tailored to the class of microbes being recognized? Several very important questions still need to be addressed.
AB - Recent studies of mucosal immunity suggest a key role for dendritic cells in the regulation of gut immune responses, in both physiological and pathological conditions. Dendritic cells are widely distributed in the lamina propria of the gut and are involved in direct bacterial uptake across mucosal surfaces, which questions the role of dendritic cells in innate mucosal responses. Approximately 400 commensal microbial species are present in the gut lumen. So how do dendritic cells distinguish pathogens from luminal microflora? Are the cytokines and chemokines induced in dendritic cells tailored to the class of microbes being recognized? Several very important questions still need to be addressed.
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UR - http://www.scopus.com/inward/citedby.url?scp=0037325009&partnerID=8YFLogxK
U2 - 10.1016/S1369-5274(03)00007-9
DO - 10.1016/S1369-5274(03)00007-9
M3 - Article
C2 - 12615223
AN - SCOPUS:0037325009
VL - 6
SP - 72
EP - 76
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
SN - 1369-5274
IS - 1
ER -