Interactions of bacterial pathogens with dendritic cells during invasion of mucosal surfaces

Francesca Granucci, Paola Ricciardi-Castagnoli

Research output: Contribution to journalArticlepeer-review

Abstract

Recent studies of mucosal immunity suggest a key role for dendritic cells in the regulation of gut immune responses, in both physiological and pathological conditions. Dendritic cells are widely distributed in the lamina propria of the gut and are involved in direct bacterial uptake across mucosal surfaces, which questions the role of dendritic cells in innate mucosal responses. Approximately 400 commensal microbial species are present in the gut lumen. So how do dendritic cells distinguish pathogens from luminal microflora? Are the cytokines and chemokines induced in dendritic cells tailored to the class of microbes being recognized? Several very important questions still need to be addressed.

Original languageEnglish
Pages (from-to)72-76
Number of pages5
JournalCurrent Opinion in Microbiology
Volume6
Issue number1
DOIs
Publication statusPublished - Feb 2003

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology

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