Objectives: To investigate whether anti-herpesvirus antibodies are associated with serum cholesterol profiles in clinically isolated syndromes (CIS). Methods: Pre-treatment serum samples from 118 high-risk CIS patients were analyzed for IgG antibodies against cytomegalovirus (anti-CMV), Epstein Barr virus (EBV) viral capsid antigen (VCA) and EBV nuclear antigen-1 (EBNA-1). A lipid profile consisting of high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) was obtained. Clinical and MRI assessments were obtained at baseline, 6, 12, and 24. months after start of interferon-beta treatment. Results: The study included 118 CIS patients (77 females, 41 males, 65.3% female; mean age: 28.1 ± SD 8.1. years). Anti-EBV EBNA-1 antibody levels were associated with LDL-C ( p= 0.009) and TC ( p= 0.008) levels. Anti-CMV positivity status was associated with reduced time to relapse ( p= 0.006) and the greater number of relapses ( p= 0.009) in patients with high HDL-C. Anti-EBV VCA antibody levels were associated with greater number of new T2 lesions ( p= 0.002) and with increased brain atrophy (p <0.001) in patients with high LDL-C. Conclusions: Our results indicate that higher levels of anti-EBV EBNA-1 antibodies are associated with higher LDL-C and TC levels. Anti-CMV positive individuals have greater disease progression in the presence of higher HDL-C levels. Individuals with higher levels of anti-EBV VCA antibodies have greater progression on MRI measures in the presence of higher LDL-C.
- Clinically isolated syndromes
- Environmental factor interactions
- Epstein-Barr virus
- Multiple sclerosis
ASJC Scopus subject areas
- Clinical Neurology
- Immunology and Allergy