Interactions of various drugs with amphetamine

S. Garattini, A. Jori, R. Samanin

Research output: Contribution to journalArticlepeer-review

Abstract

This brief review gives some examples of the possible interactions that a number of drugs may exert on (+)amphetamine. These interactions may occur at different levels, including the distribution and the metabolism of (+)amphetamine as well as the sites on which (+)amphetamine affects catecholamine functions. Due to multiplicity of action of (+)amphetamine, it is impossible to draw general conclusions. Each interaction should therefore be studied on the many pharmacological and biochemical parameters that are relevant for (+)amphetamine activity. Since it is not yet completely clear which effects of amphetamine are the result of the release of DA and/or NA, the interaction of drugs with (+)amphetamine is also difficult to interpret. It should be stressed in this respect that the studies on drug interactions have thrown considerable light on the mechanism of action of (+)amphetamine. This in turn may be of enormous importance because (+)amphetamine is utilized as a model of acute psychosis and as a tool to detect new neuroleptic agents.

Original languageEnglish
Pages (from-to)409-425
Number of pages17
JournalAnnals of the New York Academy of Sciences
VolumeVol.281
Publication statusPublished - 1976

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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