This brief review gives some examples of the possible interactions that a number of drugs may exert on (+)amphetamine. These interactions may occur at different levels, including the distribution and the metabolism of (+)amphetamine as well as the sites on which (+)amphetamine affects catecholamine functions. Due to multiplicity of action of (+)amphetamine, it is impossible to draw general conclusions. Each interaction should therefore be studied on the many pharmacological and biochemical parameters that are relevant for (+)amphetamine activity. Since it is not yet completely clear which effects of amphetamine are the result of the release of DA and/or NA, the interaction of drugs with (+)amphetamine is also difficult to interpret. It should be stressed in this respect that the studies on drug interactions have thrown considerable light on the mechanism of action of (+)amphetamine. This in turn may be of enormous importance because (+)amphetamine is utilized as a model of acute psychosis and as a tool to detect new neuroleptic agents.
|Number of pages||17|
|Journal||Annals of the New York Academy of Sciences|
|Publication status||Published - 1976|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)