Intercellular adhesion molecule-1 (ICAM-1) and granulocyte-macrophage colony stimulating factor (GM-CSF) co-expression in cutaneous malignant melanoma lesions

P. Ciotti, G. P. Pesce, F. Cafiero, M. L. Rainero, A. Sementa, G. Nicolò, G. S. Mela, M. Bagnasco, P. L. Santi, G. Bianchi-Scarrà

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Abstract

The expression of intercellular adhesion molecule-1 (ICAM1) and granulocyte-macrophage colony stimulating factor (GM-CSF) was investigated in 25 melanoma patients by evaluating 34 fresh biopsy specimens. ICAM-1 in situ hybridization and Immunochemistry for ICAM-1 and GMCSF were performed. Most of the metastatic melanoma samples (12 out of 18) and a few of the primary melanoma lesions (three out of 16) showed ICAM-1 expression. The expression of ICAM-1 was significantly (P<0.01) higher in metastatic lesions than in primary tumours. GM-CSF mRNA and protein were detected in 10 of the 18 metastatic samples and in two of the 15 primary lesions. A significantly high degree (P

Original languageEnglish
Pages (from-to)253-260
Number of pages8
JournalMelanoma Research
Volume9
Issue number3
Publication statusPublished - 1999

Keywords

  • Cytokines
  • GM-CSF
  • ICAM-1
  • Immunochemistry
  • In situ hybridization
  • Melanoma

ASJC Scopus subject areas

  • Cancer Research
  • Dermatology

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    Ciotti, P., Pesce, G. P., Cafiero, F., Rainero, M. L., Sementa, A., Nicolò, G., Mela, G. S., Bagnasco, M., Santi, P. L., & Bianchi-Scarrà, G. (1999). Intercellular adhesion molecule-1 (ICAM-1) and granulocyte-macrophage colony stimulating factor (GM-CSF) co-expression in cutaneous malignant melanoma lesions. Melanoma Research, 9(3), 253-260.