Abstract
The expression of intercellular adhesion molecule-1 (ICAM1) and granulocyte-macrophage colony stimulating factor (GM-CSF) was investigated in 25 melanoma patients by evaluating 34 fresh biopsy specimens. ICAM-1 in situ hybridization and Immunochemistry for ICAM-1 and GMCSF were performed. Most of the metastatic melanoma samples (12 out of 18) and a few of the primary melanoma lesions (three out of 16) showed ICAM-1 expression. The expression of ICAM-1 was significantly (P<0.01) higher in metastatic lesions than in primary tumours. GM-CSF mRNA and protein were detected in 10 of the 18 metastatic samples and in two of the 15 primary lesions. A significantly high degree (P
| Original language | English |
|---|---|
| Pages (from-to) | 253-260 |
| Number of pages | 8 |
| Journal | Melanoma Research |
| Volume | 9 |
| Issue number | 3 |
| Publication status | Published - 1999 |
Keywords
- Cytokines
- GM-CSF
- ICAM-1
- Immunochemistry
- In situ hybridization
- Melanoma
ASJC Scopus subject areas
- Cancer Research
- Dermatology
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Ciotti, P., Pesce, G. P., Cafiero, F., Rainero, M. L., Sementa, A., Nicolò, G., Mela, G. S., Bagnasco, M., Santi, P. L., & Bianchi-Scarrà, G. (1999). Intercellular adhesion molecule-1 (ICAM-1) and granulocyte-macrophage colony stimulating factor (GM-CSF) co-expression in cutaneous malignant melanoma lesions. Melanoma Research, 9(3), 253-260.