Intercellular adhesion molecule-1 (ICAM-1) and granulocyte-macrophage colony stimulating factor (GM-CSF) co-expression in cutaneous malignant melanoma lesions

P. Ciotti; G. P. Pesce; F. Cafiero; M. L. Rainero; A. Sementa; G. Nicolò; G. S. Mela; M. Bagnasco; P. L. Santi; G. Bianchi-Scarrà

Intercellular adhesion molecule-1 (ICAM-1) and granulocyte-macrophage colony stimulating factor (GM-CSF) co-expression in cutaneous malignant melanoma lesions

P. Ciotti, G. P. Pesce, F. Cafiero, M. L. Rainero, A. Sementa, G. Nicolò, G. S. Mela, M. Bagnasco, P. L. Santi, G. Bianchi-Scarrà

Research output: Contribution to journal › Article › peer-review

Abstract

The expression of intercellular adhesion molecule-1 (ICAM1) and granulocyte-macrophage colony stimulating factor (GM-CSF) was investigated in 25 melanoma patients by evaluating 34 fresh biopsy specimens. ICAM-1 in situ hybridization and Immunochemistry for ICAM-1 and GMCSF were performed. Most of the metastatic melanoma samples (12 out of 18) and a few of the primary melanoma lesions (three out of 16) showed ICAM-1 expression. The expression of ICAM-1 was significantly (P<0.01) higher in metastatic lesions than in primary tumours. GM-CSF mRNA and protein were detected in 10 of the 18 metastatic samples and in two of the 15 primary lesions. A significantly high degree (P

Original language	English
Pages (from-to)	253-260
Number of pages	8
Journal	Melanoma Research
Volume	9
Issue number	3
Publication status	Published - 1999

Keywords

Cytokines
GM-CSF
ICAM-1
Immunochemistry
In situ hybridization
Melanoma

ASJC Scopus subject areas

Cancer Research
Dermatology

Cite this

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title = "Intercellular adhesion molecule-1 (ICAM-1) and granulocyte-macrophage colony stimulating factor (GM-CSF) co-expression in cutaneous malignant melanoma lesions",

abstract = "The expression of intercellular adhesion molecule-1 (ICAM1) and granulocyte-macrophage colony stimulating factor (GM-CSF) was investigated in 25 melanoma patients by evaluating 34 fresh biopsy specimens. ICAM-1 in situ hybridization and Immunochemistry for ICAM-1 and GMCSF were performed. Most of the metastatic melanoma samples (12 out of 18) and a few of the primary melanoma lesions (three out of 16) showed ICAM-1 expression. The expression of ICAM-1 was significantly (P<0.01) higher in metastatic lesions than in primary tumours. GM-CSF mRNA and protein were detected in 10 of the 18 metastatic samples and in two of the 15 primary lesions. A significantly high degree (P",

keywords = "Cytokines, GM-CSF, ICAM-1, Immunochemistry, In situ hybridization, Melanoma",

author = "P. Ciotti and Pesce, {G. P.} and F. Cafiero and Rainero, {M. L.} and A. Sementa and G. Nicol{\`o} and Mela, {G. S.} and M. Bagnasco and Santi, {P. L.} and G. Bianchi-Scarr{\`a}",

year = "1999",

language = "English",

volume = "9",

pages = "253--260",

journal = "Melanoma Research",

issn = "0960-8931",

publisher = "Lippincott Williams and Wilkins",

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TY - JOUR

T1 - Intercellular adhesion molecule-1 (ICAM-1) and granulocyte-macrophage colony stimulating factor (GM-CSF) co-expression in cutaneous malignant melanoma lesions

AU - Ciotti, P.

AU - Pesce, G. P.

AU - Cafiero, F.

AU - Rainero, M. L.

AU - Sementa, A.

AU - Nicolò, G.

AU - Mela, G. S.

AU - Bagnasco, M.

AU - Santi, P. L.

AU - Bianchi-Scarrà, G.

PY - 1999

Y1 - 1999

N2 - The expression of intercellular adhesion molecule-1 (ICAM1) and granulocyte-macrophage colony stimulating factor (GM-CSF) was investigated in 25 melanoma patients by evaluating 34 fresh biopsy specimens. ICAM-1 in situ hybridization and Immunochemistry for ICAM-1 and GMCSF were performed. Most of the metastatic melanoma samples (12 out of 18) and a few of the primary melanoma lesions (three out of 16) showed ICAM-1 expression. The expression of ICAM-1 was significantly (P<0.01) higher in metastatic lesions than in primary tumours. GM-CSF mRNA and protein were detected in 10 of the 18 metastatic samples and in two of the 15 primary lesions. A significantly high degree (P

AB - The expression of intercellular adhesion molecule-1 (ICAM1) and granulocyte-macrophage colony stimulating factor (GM-CSF) was investigated in 25 melanoma patients by evaluating 34 fresh biopsy specimens. ICAM-1 in situ hybridization and Immunochemistry for ICAM-1 and GMCSF were performed. Most of the metastatic melanoma samples (12 out of 18) and a few of the primary melanoma lesions (three out of 16) showed ICAM-1 expression. The expression of ICAM-1 was significantly (P<0.01) higher in metastatic lesions than in primary tumours. GM-CSF mRNA and protein were detected in 10 of the 18 metastatic samples and in two of the 15 primary lesions. A significantly high degree (P

KW - Cytokines

KW - GM-CSF

KW - ICAM-1

KW - Immunochemistry

KW - In situ hybridization

KW - Melanoma

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M3 - Article

C2 - 10465581

AN - SCOPUS:0032860393

VL - 9

SP - 253

EP - 260

JO - Melanoma Research

JF - Melanoma Research

SN - 0960-8931

IS - 3

ER -

Intercellular adhesion molecule-1 (ICAM-1) and granulocyte-macrophage colony stimulating factor (GM-CSF) co-expression in cutaneous malignant melanoma lesions

Abstract

Keywords

ASJC Scopus subject areas

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